凌源市某医院耐碳青霉烯类肠杆菌科细菌分布及耐药性分析

Distribution and drug resistance of Carbapenem-Resistant Enterobacteriaceae in a Hospital of Lingyuan City

目的凌源市某医院耐碳青霉烯类肠杆菌科细菌(CRE)细菌分布及耐药性,为临床医师合理应用抗菌药物提供参考。方法收集2016年10月—2019年9月凌源钢城中心医院分离的CRE菌株892株,用纸片扩散法进行药敏试验,统计细菌分布情况,分析耐药性。结果CRE菌株中克雷伯菌属、大肠埃希菌属、肠杆菌属占比分列前三位,占比分别为57.06%、12.11%、9.75%,呼吸道、尿液、血液占标本来源前三位,占比分别为58.97%、19.06%、6.05%;CRE菌株对阿米卡星耐药率<50.00%,其余抗菌药物耐药率为50.00%~96.72%。结论CRE菌株对临床常用抗菌药物耐药性较高,菌株分布院内不同病区存在差异,菌株分布及耐药情况能够为临床上感染控制提供科学借鉴经验,预防其在院内传播。

Objective To analyze the distribution and drug resistance of Carbapenem-Resistant Enterobacteriaceae(CRE)in a Hospital of Lingyuan City,so as to provide reference for clinicians to use antibiotics reasonably.Methods 892 strains of CRE isolated from Lingyuan Steel City Central Hospital from October 2016 to September 2019 were collected for drug sensitivity test by disk diffusion method,bacterial distribution and drug resistance analysis.Results Among CRE strains,Klebsiella,Escherichia coli and Enterobacteriaceae were the top three,accounting for 57.06%,12.11%and 9.75%respectively.Respiratory tract,urine and blood were the top three,accounting for 58.97%,19.06%and 6.05%respectively.The resistance rate of CRE strains to amikacin was lower than 50.00%,and the resistance rate of other antibiotics was in the range of 50.00%-96.72%.Conclusion CRE strains are highly resistant to commonly used clinical antibiotics,and their distribution in different hospital areas is different.The distribution and drug resistance of CRE strains can provide scientific experience for clinical infection control and prevent its spread in hospital.