异基因造血干细胞移植后迟发性非感染性肺部并发症的研究进展

Study advances in late-onset noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

异基因造血干细胞移植(HSCT)是一种治疗各种血液、肿瘤和先天性疾病的方法。肺部并发症在HSCT受者中很常见,近30%的移植后死亡与肺部并发症有关。降低移植强度及有效的抗感染治疗降低了早期移植相关死亡率,但晚期移植相关死亡仍然是个问题。与此同时,随着术前术后广谱抗生素的合理使用,近年来HSCT后肺部并发症疾病谱越来越多地从感染性变为非感染性。本文综述了各种迟发性非感染性肺部并发症及其研究进展。

Allogeneic hematopoietic stem cell transplantation(HSCT)is a treatment for a variety of blood,tumor and congenital diseases.Pulmonary complications are common in HSCT recipients and associated with nearly 30%of post-transplant deaths.Reduced graft strength and effective anti-infective treatment can reduce early graft related mortality,but late graft related mortality remains a problem.Meanwhile,with the rational use of broad-spectrum antibiotics before and after surgery,the spectrum of pulmonary complications after HSCT has increasingly changed from infectious to non-infectious in recent years.This paper reviews the recent advances in the study of late-onset noninfectious pulmonary complications.