基于数据挖掘的芡实方剂配伍规律研究

Study on Compatibility Rule of Semen Euryales Prescription Based on Data Mining

目的探寻古方中芡实的药物组方配伍规律。方法以《中华医典》《中医方剂大辞典》《普济方》为数据采集源,收集整理1103首含有芡实的方剂,运用频次统计、关联规则挖掘芡实古方中的用药频次、常用配伍中药、方剂剂型、药物的性味归经、功效等规律。结果芡实古方涉及其他中药累计681味,药物频次共11633次,芡实常与茯苓、山药、莲子、熟地黄、人参、白术等药配伍应用,各药对配伍时常用比例为1∶1。芡实相关方剂的药物功效分析,排名前4位的分别为补脾止泻、益肾固精、除湿止带、利水渗湿。含芡实的常用方剂中药物组合有6个,其中2味药药物组合2个,3味药药物组合4个。结论数据挖掘技术可揭示芡实在方剂中的用药规律,为相关研究提供参考理论依据,为现代制剂的开发提供参考。

Objective To excavate the compatibility law of Semen Euryales in ancient prescriptions.Methods Using The Chinese Medical,Dictionary of Chinese Medicine Prescriptions,Puji Benshi Fang as the data collection source,1103 prescriptions were collected and sorted out.The frequency statistical,association rules were used to explored the laws of medication frequency,commonly used compatibility,dosage form,nature and flavor,meridian tropism and effect.Results Ancient prescriptions containing Semen Euryales involved other 681 types of Chinese materia medica,and 11633 times of herbs.Semen Euryales often used with Poria,Rhizoma Dioscoreae,Semen Nelumbinis,Radix Rehmanniae Preparata,Radix Ginseng,Rhizoma Atractylodis Macrocephalae and other herbs.The most commonly used ratio for compatibility was 1∶1.The herb function analysis of Semen Euryales related herbs showed that the top four were supplementing the spleen to arrest diarrhea,benefiting the kidney and consolidating essence,eliminating dampness to arrest vaginal discharge,promoting urination and diffusing dampness.A total of 6 commonly used drug combinations containing Semen Euryales were obtained,including 2 combinations of 2 herbs,4 combinations of 3 herbs.Conclusion The data mining technology can reveal the medication law of Semen Euryales in the prescription,provide theoretical basis for related research reference,and provide reference for the development of modern preparations.