基于数据挖掘分析膝骨关节炎外用方用药规律

Analysis of the Rule of Prescription for External Use of Knee Osteoarthritis Based on Data Mining

目的借助数据挖掘技术总结中药外用治疗膝骨关节炎(kneesteoarthritis,KOA)的用药规律,为中药外用治疗KOA提供参考。方法通过计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据学术论文总库(WanFang Data)、中国生物医学文献数据库(CBM),收集整理建库至2019年12月9日中药外用治疗KOA的临床随机对照试验(RCT),对所采集处方的用药特点、药物剂量及性味归经进行频数、聚类及关联规则分析。结果共155篇文献纳入统计分析,频数分析显示高频药物为透骨草、红花、伸筋草、当归、威灵仙、乳香、没药等20味中药;聚类分析发现5个有效聚类群,Ⅰ类为生川乌、生草乌,Ⅱ类为木瓜、羌活、鸡血藤、川芎,Ⅲ类为海桐皮、花椒、艾叶,Ⅳ类为伸筋草、透骨草、红花,Ⅴ类为乳香、没药;关联规则得到19组核心用药组合,其中4组关联规则最强。结论中药外用治疗KOA以祛风除湿、活血化瘀为核心,并辅以温经通络。

Objective To summarize the medication law of external use of Chinese materia medica for knee osteoarthritis(KOA)with the help of data mining technology,and provide a reference for external use of Chinese materia medica to treat KOA.Methods The Chinese Journal Full-text Database(CNKI),VIP Chinese Scientific and Technical Periodical Database(VIP),WanFang Data Academic Papers Database(WanFang Data),and Chinese Biomedical Literature Database(CBM)were searched by computer to collect randomized controlled trials(RCTs)on external use of Chinese materia medica to treat KOA from database establishment to December 9,2019.Analysis of frequency,clustering and association rules were performed on the characteristics of the medication,the dose of the medication,and the nature and flavor of the collected prescriptions.Results A total of 155 papers were included in the statistical analysis.Frequency analysis showed that the high-frequency herbs were 20 Chinese materia medica such as Garden Balsam Stem,Flos Carthami,Herba Lycopodii,Radix Angelicae Sinensis,Radix Clematidis,Olibanum,and Myrrha;cluster analysis found 5 effective clusters:Class I:Radix Aconiti,Radix Aconiti Kusnezoffii;Class II:Fructus Chaenomelis,Rhizoma et Radix Notopterygii,Caulis Spatholobi,Rhizoma Ligustici Chuanxiong;Class III:Erythrina Indica Lam,Pericarpium Zanthoxyli,Folium Artemisiae Argyi;Class IV:Herba Lycopodii,Garden Balsam Stem,Flos Carthami;Ⅴ:Olibanum,Myrrha.Association rules obtained 19 core herb combinations,of which 4 groups had the strongest association rules.Conclusion External use of Chinese materia medica in the treatment of KOA is to remove wind and dampness,promote blood circulation and remove blood stasis,and supplement it with warming meridians for removing obstruction in collaterals.