巨噬细胞移动抑制因子与精神分裂症关联的研究进展

Research progress of macrophage migration inhibitory factor in schizophrenia

精神分裂症是一种复杂且严重的精神疾病,其发病机制尚未明确。炎症假说表明,人体的免疫紊乱所致的神经炎症与精神分裂症的发病机制相关。巨噬细胞移动抑制因子(MIF)是一种具有广泛免疫调节特性的细胞因子,近年来被广泛研究于各种疾病,有证据表明MIF与精神分裂症有一定关联,但其主要机制未明,现主要阐述MIF在精神分裂症中的研究进展。

Schizophrenia is a complex and serious mental disease,and its true pathogenesis is not yet clear.The inflammation hypothesis indicates that the neuroinflammation caused by the immune disorder of the human body is related to the pathogenesis of schizophrenia.In recent years,macrophage migration inhibitory factor(MIF)is a cytokine with a wide range of immunomodulatory properties.It has been widely studied in various diseases.There is evidence that MIF is associated with schizophrenia.However,its main mechanism is unknown.This paper mainly describes the research progress of MIF in schizophrenia.