早期NCPAP对改善34周内早产儿呼吸窘迫综合征预后的临床分析

Clinical analysis of early NCPAP in improving the prognosis of respiratory distress syndrome in premature infants within 34 weeks

目的探讨早期经鼻持续气道正压通气(NCPAP)对改善34周内早产儿呼吸窘迫综合征(NRDS)预后的临床效果。方法选取2018年3月~2019年11月我院治疗的NRDS早产儿86例作为研究对象,按照随机数字表法将其分对照组(43例)与观察组(43例),对照组采用氨溴索治疗,观察组采用氨溴索联合早期NCPAP治疗。比较不同时间点两组患儿血气分析结果、治疗情况及并发症发生情况。结果观察组血液酸碱度(pH)、氧合指数(OI)高于对照组,动脉血二氧化碳分压(PaCO2)、机械通气比例、并发症总发生率均低于对照组,氧疗时间、住院时间短于对照组,差异有统计学意义(P<0.05)。结论早期NCPAP辅助治疗NRDS患儿效果更好,能改善患儿血气指标,降低机械通气比例,缩短患儿治疗时间,减少并发症的发生,有助于早产儿尽早恢复,值得推广。

Objective To investigate the clinical effect of early nasal continuous positive airway pressure(NCPAP)in improving the prognosis of respiratory distress syndrome(NRDS)in premature infants within 34 weeks.Methods A total of 86 premature infants with NRDS treated in our hospital from March 2018 to November 2019 were selected as the research objects,and they were divided into control group(43 cases)and observation group(43 cases)according to the random number table method.The control group was treated with Ambroxol,and the observation group was treated with Ambroxol and early NCPAP.The results of blood gas analysis,treatment and complications were compared between the two groups at different time points.Results The blood power of hydrogen(pH)and oxygenation index(OI)in observation group were higher than those in control group,the arterial partial pressure of carbon dioxide(PaCO2),ratio of mechanical ventilation and the total incidence of complications in observation group were lower than those in control group,and the time of oxygen therapy and hospitalization time in observation group were shorter than those in control group,the differences were statistically significant(P<0.05).Conclusion Early NCPAP in adjuvant treatment of NRDS has better effect,it can improve blood gas indexes,decrease the ratio of mechanical ventilation,shorten the treatment time of children,reduce the incidence of complications and promotes recovery of premature infants,which is worthy of promotion.