儿童NS糖皮质激素治疗与25羟基维生素D3的关系

The relationship between glucocorticoid therapy and 25 hydroxyvitamin D in children with nephrotic syndrome

肾病综合征(NS)是儿童泌尿系统疾病中常见的慢性疾病,目前糖皮质激素是治疗儿童NS免疫抑制剂中的首选用药。长期、大量应用糖皮质激素对于正处在生长发育阶段的儿童有很大的影响,近年来,激素的副作用已引起临床儿科工作者的重视。25羟基维生素D3[25-(OH)D3]是调节骨代谢的主要激素。该文对糖皮质激素在治疗儿童NS过程中与25-(OH)D3的关系进行综述。

Nephrotic syndrome(NS) is a common chronic disease of urinary system in children.Glucocorticoids are currently the preferred drug in the treatment of NS immunosuppressive agents in children.Long-term and massive use of glucocorticoids has a great impact on children at the stage of growth and development.In recent years,the side effects of hormone therapy have attracted the attention of clinical pediatricians.25 hydroxyvitamin D3 [25(OH)D3] is the main hormone that regulates bone metabolism.This article reviews the relationship between glucocorticoids and 25(OH)D3 in the treatment of NS children.