低分子肝素联合阿司匹林治疗复发性流产的临床效果分析

Clinical effect analysis of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion

目的研究低分子肝素联合阿司匹林治疗复发性流产的临床效果。方法选取2018年1月至2020年1月浙江省台州医院收治的复发性流产患者88例为研究对象,按随机数字表分为两组,对照组和研究组各44例。对照组应用阿司匹林治疗,研究组应用低分子肝素联合阿司匹林治疗,对比两组患者的保胎成功率、不良反应、激素水平以及免疫功能。结果研究组保胎成功率高于对照组(χ^2=6.132,P<0.05),不良妊娠结局发生率低于对照组(χ^2=5.834,P<0.05);研究组不良反应的发生率差异无统计学意义(χ^2=1.524,P>0.05);研究组孕酮、人绒毛膜促性腺激素(HCG)、雌二醇改善均优于对照组(t值分别为20.357、21.477、12.365,均P<0.05);研究组γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)、IFN-γ/IL-4改善均优于对照组(t值分别为10.657、22.335、31.158,均P<0.05)。结论低分子肝素联合阿司匹林治疗复发性流产效果理想,能够改善产妇的妊娠结局,而且不会增加治疗期间出现的不良反应,具有较高的安全性,建议临床上进一步推广应用。

Objective To investigate the clinical effect analysis of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion.Methods A total of 88 patients with recurrent abortion admitted to Taizhou Hospital of Zhejiang Province from January 2018 to January 2020 were selected as the study subjects.According to the random number table,they were divided into two groups,44 cases in each of the control group and the study group.The control group was treated with aspirin,while the study group was treated with LMWH combined with aspirin.The effects of the two groups on the success rate of fetal preservation,immune function and occurrence of adverse reactions were compared.Results The success rate of fetal preservation in the study group was higher than that of the control group(χ2=6.132,P<0.05),and the incidence of adverse pregnancy outcomes was lower than that of the control group(χ2=5.834,P<0.05).The incidence of adverse reactions was no significant difference between the two groups(χ2=1.524,P>0.05).The improvements of progesterone,HCG and E2 in the study group were better than those in the control group(t values were 20.357,21.477 and 12.365,respectively,all P<0.05).The improvements of IFN-I,il-4 and IFN-I/il-4 in the study group were better than those in the control group(t values were 10.657,22.335 and 31.158,respectively,all P<0.05).Conclusion In the treatment of recurrent abortion,low molecular weight heparin combined with aspirin has an ideal therapeutic effect,can improve maternal pregnancy outcome,and will not increase the adverse reactions during treatment,which has a high safety and should be further popularized in clinical application.