轻度认知障碍患者焦虑、抑郁情绪与认知的关系研究

Relationship between anxiety,depression and cognitive in patients with mild cognitive impairment

目的:探讨轻度认知障碍(MCI)患者焦虑、抑郁情绪与认知功能的关系。方法:采用便利抽样法,于2019年1—12月对北京某三级甲等医院多学科联合记忆门诊就诊的727例老年患者进行记忆筛查,在征得其同意后,对其中的247例MCI患者使用蒙特利尔认知评估量表(MoCA)、广泛性焦虑量表(GAD-7)、患者健康问卷抑郁量表(PHQ-9)进行调查。结果:共发放问卷247份,回收有效问卷233份。233例MCI患者合并焦虑抑郁67例(28.8%),仅焦虑11例(4.7%),仅抑郁53例(22.7%),无焦虑抑郁102例(43.8%);MCI患者焦虑与延迟回忆呈正相关(P<0.05),抑郁与语言功能呈负相关(P<0.05);不同情绪状态的MCI患者在语言功能方面差异有统计学意义(P<0.05)。结论:MCI患者合并焦虑、抑郁的发生率较高,且焦虑、抑郁会影响MCI患者认知功能的不同维度。医务人员需要针对MCI患者的不同情绪特点给予有针对性的干预措施。

Objective To explore the relationship between anxiety,depression and various dimensions of cognitive function in patients with mild cognitive impairment(MCI).Methods The convenient sampling method was adopted to conduct memory screening for 727 elderly people who visited the multidisciplinary joint memory clinic of a ClassⅢGrade A hospital in Beijing from January to December 2019.With their consent,247 MCI patients were investigated using Montreal Cognitive Assessment(MoCA),Generalized Anxiety Disorder(GAD-7)and Patient Health Questionnaire(PHQ-9).Results A total of 247 questionnaires were distributed and 233 valid questionnaires were returned.There were 67 cases(28.8%)of MCI patients with anxiety and depression,11 cases(4.7%)with anxiety,53 cases(22.7%)with depression and 102 cases(43.8%)without anxiety and depression.In MCI patients,anxiety was positively correlated with delayed recall(P<0.05),while depression was negatively correlated with language function(P<0.05).MCI patients with different emotional states had statistically significant differences in language function(P<0.05).Conclusions MCI patients have a higher incidence of anxiety and depression,and anxiety and depression will affect different dimensions of cognitive function in MCI patients.Medical staff need to provide targeted interventions for MCI patients with different emotional characteristics.