连续流反应技术在药物分子合成中的研究进展

Study Progress of Continuous Flow Technology in Drug Molecular Synthesis

流动化学技术具有高传热与传质效率、高反应安全性、短反应时间以及可精准控制反应参数等优点而在药物合成中具有重要潜力。分别从流动化学中气-液反应、固-液反应、气-液-固反应、液-液反应、液-液-固反应体系在药物合成中的研究进展进行综述。为今后流动化学技术在药物合成中的进一步应用提供借鉴。

Flow chemistry technology has the advantages of high heat and mass transfer efficiency,high reaction safety,short reaction time and accurate control of reaction parameters,which has important potential in drug synthesis.The research progress of continuous flow technology with gas-liquid reaction,solid-liquid reaction,gas-liquid-solid reaction,liquid-liquid reaction and liquid-liquid-solid reaction system in drug synthesis were reviewed.It provides a reference for the further application of flow chemistry technology in drug synthesis.