宫腔灌注胚胎培养上清液对冻融胚胎移植的影响研究

The impact of intrauterine perfusion of embryo culture supernatant on frozen-thawed embryo tansfer outcome

目的探索冻融胚胎移植周期胚胎移植前宫腔灌注胚胎培养上清液对胚胎种植及妊娠结局的影响。方法纳入我院2019年3月—2019年12月共计198个冻融胚胎移植(frozen-thawed embryo transfer,FET)周期。根据FET术前是否予胚胎培养液上清液宫腔灌注操作分成2组,灌注组93个周期,对照组即未灌注组105个周期。灌注组分别于FET术前4周和术前1天行宫腔灌注胚胎培养上清液,对照组未行胚胎培养上清液宫腔灌注,对比两组患者胚胎着床率、临床妊娠率、流产率。结果灌注组患者的胚胎着床率高于对照组,差异有统计学意义(P<0.05)。两组间的临床妊娠率、流产率未见统计学差异(P>0.05)。结论FET术前宫腔灌注胚胎培养上清液可提高胚胎种植率。

Objective To investigate the potential impact of intrauterine perfusion of embryo culture supernatant before frozen-thawed embryo transfer(FET)on pregnancy outcome.Methods From March to December 2019,a total of 198 FET cycles were enrolled for the present study.Patients were divided into two groups:the study group included 93 cycles,patients in this group received intrauterine perfusion of embryo culture supernatant four weeks and one day before the embryo transfer,respectively;the control group included 105 cycles,and patients in this group did not receive intrauterine perfusion.Rates of implantation,pregnancy,and miscarriage were compared between the two groups.Results The implantation rate in the study group was higher than that in the control group(P<0.05).There were no significant differences in clinical pregnancy rate and abortion rate between the two groups(P>0.05).Conclusion With the performance of intrauterine perfusion of embryo culture supernatant before embryo transfer,the implantation rate may be improved in FET cycles.