红花注射液联合塞来昔布治疗腰椎间盘突出症临床研究

Clinical study of Honghua Injection combined with celecoxib in treatment of lumbar disc herniation

目的探索红花注射液联合塞来昔布治疗腰椎间盘突出症的临床疗效。方法选取2017年9月—2019年7月焦作市人民医院收治的50例腰椎间盘突出症患者作为研究对象,随机数字表法将患者分为对照组(n=25)和观察组(n=25)。两组均给予经皮穿刺低温等离子消融术治疗,对照组口服塞来昔布胶囊,200 mg/次,1次/d。观察组在对照组治疗的基础上在病变椎间盘下一个椎体棘突旁侧注射红花注射液,10 mL,1次/d。两组共给药14 d。观察两组患者的临床疗效,同时比较两组患者的Oswestry功能障碍指数(ODI)、视觉模拟评分法(VAS)评分、血浆P物质、血浆β-内啡肽(β-EP)、白细胞介素-6(IL-6)、一氧化氮(NO)和Pfirrmann分级情况。结果治疗后,对照组和观察组为总有效率比较差异无统计学意义。治疗后,两组患者的ODI评分和VAS评分均显著降低(P<0.05);且观察组ODI评分和VAS评分均显著低于对照组(P<0.05)。治疗后,两组P物质和β-EP水平显著升高,而IL-6和NO水平显著降低(P<0.05);且观察组P物质和β-EP水平显著高于对照组,而观察组IL-6和NO水平显著低于对照组(P<0.05)。两组Pfirrmann III级患者均高于IV级(P<0.05)。结论红花注射液联合塞来昔布治疗腰椎间盘突出症可提高患者腰椎功能,改善炎症状态,有效缓解患者疼痛,调控炎症因子及镇痛物质表达。

Objective To explore the clinical effect of Honghua Injection combined with Celecoxib in treatment of lumbar disc herniation.Methods A total of 50 patients with lumbar disc herniation admitted to Jiaozuo People’s Hospital from September 2017 to July 2019 were selected as the research objects,and the patients were divided into control group(n=25)and observation group(n=25)by random number table method.Both groups were treated with percutaneous low-temperature plasma ablation,while patients in the control group were po administered with Celecoxib Capsules,200 mg/time,once daily.Patients in the observation group were injected with Honghua Injection on the basis of control group at the side of the vertebral spine process under the diseased intervertebral disc,10 mL,once daily.Patients in two groups were treated for 14 days.After treatment,the clinical efficacy in two groups was observed.And the ODI score,VAS score,plasma substance P,β-EP,IL-6,NO,and Pfirrmann grade were compared between two groups.Results After treatment,there was no statistically significant difference in the total effective rate between control group and observation group.After treatment,tHE ODI score and VAS score in two groups were significantly decreased(P<0.05).Moreover,ODI score and VAS score in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of substance P andβ-EP were significantly increased in two groups,while the levels of IL-6 and NO were significantly decreased(P<0.05).Moreover,the levels of substance P andβ-EP in the observation group were significantly higher than those in the control group,while the levels of IL-6 and NO in the observation group were significantly lower than those in the control group(P<0.05).Pfirrmann III patients in two groups were higher than grade IV patients(P<0.05).Conclusion Honghua Injection combined with celecoxib in treatment of lumbar disc herniation can improve the function of the lumbar spine,and the inflammatory state,effectively relieve the pain of patients,regulate the expression of inflammatory factors and analgesic substances.