血清瘦素与绝经后2型糖尿病女性患者骨密度的相关性研究

Correlation between serum leptin and bone mineral density in postmenopausal patients with type 2 diabetes mellitus

目的探索血清瘦素与绝经后2型糖尿病患者骨密度的相关性。方法共纳入98名2型糖尿病女性进行分析,通过双能X线骨密度仪对受试者髋部BMD进行检查,并测定T评分,按照骨密度检测结果分为骨质疏松症组(PMOPW)以及非骨质疏松组(PMW)。对照组按照BMI与骨质疏松症受试者匹配。通过酶联免疫吸附法(ELISA)测定检测血清瘦素水平。结果两组血清瘦素和BMD值差异均有统计学意义(瘦素,(18.23±8.56)ng/mL vs(22.44±9.56)ng/mL,P<0.05)和(BMD,(-0.74±0.13)vs(-3.127±0.55),P<0.05)。在PMOPW中,血清瘦素和BMD与体重、BMI、腰围、臀围显著相关。多元线性逐步回归分析显示PMW和PMOPW的体重和BMI是BMD的独立预测因子。未发现血清瘦素水平是两组BMD的预测因子。结论体重和BMI对2型糖尿病患者BMD影响显著,但是未发现血清瘦素与PMW和PMOPW的BMD有关。

Objective To explore the correlation between serum leptin and bone mineral density(BMD)in postmenopausal patients with type 2 diabetes.Methods A total of 98 women with type 2 diabetes were enrolled in the study.The hip BMD was examined using dual-energy X-ray absorptiometry,and the T-score was determined.The patients were divided into osteoporosis group(PMOPW)and the non-osteoporosis group(PMW)according to BMD test result.The subjects in control group were matched with osteoporosis subjects according to BMI.Serum leptin levels were measured using enzyme-linked immunosorbent assay(ELISA).Results Serum leptin(18.23±8.56ng/mL versus 22.44±9.56ng/mL,P<0.05)and BMD values(-0.74±0.13 versus-3.127±0.55,P<0.05)were significantly different between the two groups,respectively.In PMOPW,serum leptin and BMD were significantly correlated with weight,BMI,waist circumference,and hip circumference.Multivariate linear stepwise regression analysis showed that weight and BMI in PMW and PMOPW were independent predictors of BMD.Serum leptin level was not found to be the predictor of BMD in both groups.Conclusion This study shows that body weight and BMI have significant effects on BMD in patients with type 2 diabetes,but serum leptin is not associated with BMD in PMW and PMOPW.