Notch信号通路在骨髓间充质干细胞及骨代谢疾病中的功能研究进展

Research progress in the function of Notch signaling pathway in bone marrow mesenchymal stem cells and bone metabolic diseases

骨髓间充质干细胞是存在于骨髓基质中的一种多能干细胞,具有多向分化的潜能,其天然再生能力对骨骼的生长代谢和骨转换起着至关重要的作用。Notch信号通路是一条在进化中高度保守的信号转导通路,与骨髓间充质干细胞的增殖、分化与凋亡密切相关,影响人体骨骼发育,也是多种骨代谢疾病的重要调节通路。以往对Notch信号通路的研究主要集中在神经干细胞,对骨髓间充质干细胞的研究较少。本文通过查阅文献,阐述不同的影响因素介导Notch信号通路对骨髓间充质干细胞分化的调节,并总结了Notch信号通路在骨代谢疾病如Alagille综合征、Adams Oliver综合征、脊椎肋骨发育不良、Hajdu-Cheney综合征、骨折愈合中的研究近况。

Bone marrow mesenchymal stem cells(BMSCs)are pluripotent stem cells that are present in the bone marrow stroma and potential for multi-directional differentiation.Their natural regenerative capacity plays an important role in bone growth and metabolism and bone turnover.Notch signaling pathway is a highly conserved signal transduction pathway in evolution.It is related to the growth,differentiation,and apoptosis of bone marrow mesenchymal stem cells,affecting human bone development,and is also an important regulatory pathway for various bone metabolic diseases.Previous studies of the Notch signaling pathway are mainly focused on neural stem cells,and little is concerned on BMSCs.This paper describes the regulation of BMSCs by different factors through Notch signaling pathway by literature searching,and summaries the recent research of Notch signaling pathway in metabolic diseases such as Alagille syndrome,Adams Oliver syndrome,spinal rib dysplasia,Hajdu-Cheney syndrome,and fracture healing.