摘要
通过体外循环膜肺添加一氧化氮气体,发挥一氧化氮抗炎、氧化游离血红蛋白、改善循环等作用,临床显示对心脏和肾脏有明确保护作用,对肺脏的保护作用不明确。该模式使用一氧化氮有可能产生高铁血红蛋白血症、二氧化氮、增加出血风险以及出现肺高压反跳。对于膜肺加入一氧化氮的时机、治疗浓度、不同膜肺的通透性等诸多方面,仍需进一步研究。
Nitric oxide(NO)can inhibit inflammation,oxidize free hemoglobin and improve circulation.NO has been dem⁃onstrated to have a myocardial and renal protective effect by delivering to the membrane oxygenator during cardiopulmonary bypass(CPB).It also has adverse reactions such as methemoglobinemia formation,nitric dioxide(NO2)production,bleeding and pulmonary hypertension rebound.It is necessary to further explore the appropriate time of administration,optimal concentration and permeability of different oxygenators.
作者
要惜梦(综述)
周成斌(审校)
Yao Ximeng;Zhou Chengbin(Department of Cardiac Surgery,Guangdong Cardiovascular Institute,Guangdong Provincial Key Laboratory of South China Structural Heart Disease,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)
出处
《中国体外循环杂志》
2020年第5期317-320,共4页
Chinese Journal of Extracorporeal Circulation
基金
国家科技计划项目(2018YFC1002600)
广东省科技计划项目(2017A070701013,2017B090904034,2017B030314109)。
关键词
一氧化氮
体外循环
膜肺
心肌保护
Nitric oxide
Cardiopulmonary bypass
Oxygenators
Myocardial protection
