滤泡辅助性T细胞在B细胞淋巴瘤免疫微环境中作用的研究进展

Research progress on follicular helper T cell in immune microenviroment of B cell lymphoma

滤泡辅助性T细胞(Tfh)是一种新发现的CD4+T细胞,其对维持机体生发中心活性及体液免疫平衡至关重要。近期多项研究结果表明,Tfh在T细胞淋巴瘤免疫微环境中具有重要作用,而其在B细胞淋巴瘤(BCL)中作用的文献迄今较少。笔者通过对Tfh的分类与功能、BCL的起源及其免疫微环境,以及Tfh与BCL免疫微环境的关系等,对Tfh在BCL免疫微环境中作用的研究进展进行综述。

Follicular helper T cell(Tfh)is a new subset CD4+T cells that is essential for maintaining the activity of germinal center and the balance of humoral immune.Recently,some studies have shown that Tfh played an important role in the immune microenvironment of T cell lymphomas,but there are fewer related studies in B cell lymphoma(BCL).This article reviews the role of Tfh in BCL through the classification and function of Tfh,the origin of BCL and it′s immune microenviroment,and the relationship between Tfh and immune microenviroment of BCL.