中老年人群25-羟维生素D水平与血脂的相关性研究

The correlation between 25 hydroxyvitamin D level and blood lipid in middle-aged and old people

目的探讨中老年人群血清25-羟维生素D[25(OH)D]缺乏与血脂水平的相关性。方法纳入2019年5至6月合肥市庐阳区某社区50岁以上居民205例作为研究对象并完成标准化问卷调查,收集性别、年龄等一般资料,采集空腹静脉血,检测血液生化相关指标。按血清中25(OH)D水平,分为维生素D缺乏组、维生素D不足组及维生素D充足组3组,采用方差分析和kruscal-Wallis H检验比较各组之间临床资料的差异,多重线性回归分析显示25(OH)D与血脂水平及相关指标的关系。结果205例受试人群25(OH)D水平范围为9.61~53.36μg/L,25(OH)D水平(23.90±8.45)μg/L。其中维生素D缺乏及不足者共168例,比例高达81.95%。不同25(OH)D水平的各组间肾小球滤过率估值(H=10.015,P<0.05)、总胆固醇(H=6853,P<0.05)、脂蛋白a(H=9.144,P<0.05)、血红蛋白(H=6.101,P<0.05)、N端中段骨钙素(H=6.705,P<0.05)、总I型胶原氨基端延长肽(H=7.349,P<0.05)差异有统计学意义。多重线性回归分析显示三酰甘油(TG)与25(OH)D呈负相关(F=3.725,P<0.001,调整R方=0.118)。结论中老年人群维生素D缺乏常见,并可能与中老年TG增高有关。

Objective To assess the relationship between 25 hydroxyvitamin D deficiency and lipid levels in the elderly.Methods From May to June 2019,205 residents over 50 years old in a community of Luyang District of Hefei city were included in the study,and standardized questionnaire survey was completed to collect general data such as gender and age.Besides,fasting venous blood was collected,and blood biochemical indicators were detected.According to the level of 25(OH)D in serum,people were divided into three groups:vitamin D deficiency group,vitamin D insufficient group and vitamin D sufficient group.The differences of clinical data between the three groups were compared by variance analysis and krucal-Wallish H test.Multiple linear regression analysis was used to show the relationship between 25(OH)D and blood lipid level and related indexes.Results The level of serum 25(OH)D in 205 subjects ranged from 9.61 to 53.36 ng/mL,with an average of(23.90±8.45)ng/mL.Among them,168 subjects were deficient in vitamin D,accounting for 81.95%.There were significant differences in EGFR(H=10.015,P<0.05),TC(H=6853,P<0.05),lipoprotein a(H=9.144,P<0.05),Hb(H=6.101,P<0.05),N-MID Osteocalcin(H=6.705,P<0.05),and total amino terminal elongation peptide of type I collagen(H=7.349,P<0.05).Multiple linear regression analysis showed that triglyceride(TG)was negatively correlated with 25(OH)D(F=3.725,P<0.001,Adjusted R-Square=0.118).Conclusion The status of vitamin D deficiency in the elderly is common,which is related to the serum TG increase.