基于数据挖掘方法总结王树声教授治疗上尿路结石的用药经验

The Study of Professor Wang Shu-sheng's Experience in the Treatment of Upper Urinary Calculi Based on Data Mining

目的:运用中医传承辅助平台系统(V2.5)深入分析王树声教授治疗上尿路结石的用药经验,挖掘其核心经验方组成和辨证用药规律。方法:收集王教授门诊治疗上尿路结石的治疗验方304首,将方药信息录入系统,采用药物频次统计、关联规则分析和熵聚类分析等方法分析处方用药规律。结果:304首处方中涉及中药97味,用药频次超过100次的有14味。所用药物药性多寒、温、平,药味多甘、苦,主归肝、肾、脾经;共得出25组核心组合和9首新处方。结论:王教授治疗上尿路结石以益气固本、清热通淋为主,用药的关键在于“扶正固本”的把握和“祛邪通淋”的权衡,为临证用药和新方开发提供参考。

Objective The TCMIPS v2.5 software was used to construct Professor Wang Shu-sheng’s clinical database for the treatment of upper urinary calculi and excavate his core experience prescription composition as well as dialectical medication law.Methods The 304 prescriptions from Professor Wang in treating upper urinary calculi were collected and recorded into TCM inheritance system.Medication laws and combination regularities were explored and analyzed with the application of data mining methods such as drug frequency analysis,association rule analysis and entropy clustering analysis.Results Total 304 prescriptions were collected in the treatment of upper urinary calculus and 97 herbs were used.The analysis showed that 14 herbs appeared for more than 15 times.Most of the herbs were sweet and bitter in flavor and cold,warm and smooth in nature,mainly related to liver,kidney and spleen meridians.25 key herbal combinations and 9 new prescriptions were discovered.Conclusion Professor Wang's treatment of upper urinary tract calculi is mainly based on invigorating Qi and strengthening the foundation,clearing away heat and clearing away drench.The key of medication lies in the balance between strengthening the foundation,eliminating pathogenic factors and clearing away drench,which provides reference for clinical medication and the development of new prescriptions.