阿托伐他汀联合依折麦布与双倍剂量阿托伐他汀对冠心病患者调脂疗效的meta分析

The lipid-regulating effects of the atorvastatin combined with ezetimibe and the double-dose atorvastatin in patients with coronary heart disease:a meta-analysis

目的:评价阿托伐他汀联合依折麦布(联合组)与双倍剂量阿托伐他汀(他汀组)对冠心病患者的血脂调节效果。方法:检索中国知网(CNKI)及PubMed,收集2010—2020年发表的两组治疗冠心病患者的随机对照试验,对纳入文献采用RevMan 5.3软件进行meta分析。结果:共纳入11项研究,合计2418例患者。meta分析显示,与他汀组相比,联合组显著降低血浆低密度脂蛋白胆固醇(LDL-C)水平和胆固醇(TC)水平,显著升高高密度脂蛋白胆固醇(HDL-C)水平,而在降低甘油三酯(TG)水平方面差异没有统计学意义。结论:对于冠心病患者,联合组在降低LDL-C和TC、升高HDL-C水平方面效果优于他汀组,而在TG水平的改变方面没有明显差异。

Objective:To evaluate the lipid-regulating effect of the atorvastatin combined with ezetimibe(combination group)and the double-dose atorvastatin(statin group)in patients with coronary heart disease.Methods:Randomized controlled trials(RCTs)in the two groups in the treatment of patients with coronary heart disease from 2010-2020 were retrieved and collected from CNKI and PubMed and meta-analysis was conducted using RevMan 5.3 statistical software for included literature.Results:A total of 11 RCTs were included involving 2418 patients.The results of meta-analysis showed that compared to statin group,combination group significantly decreased the levels of plasma low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC)and significantly increased the level of high-density lipoprotein cholesterol(HDL-C).There was no statistical significance in decreasing the level of triglyceride(TG).Conclusion:For patients with coronary heart disease,the combination group is more effective in decreasing the levels of LDL-C and TC and increasing the level of HDL-C than the statin group and there is no significant difference in the change of TG level.