不同剂量阿立哌唑对奥氮平治疗精神分裂症稳态血药浓度的影响

Effect of Different Doses of Aripiprazole on the Steady State Plasma Concentration of Olanzapine in the Treatment of Schizophrenia

目的探讨联用不同剂量阿立哌唑对奥氮平治疗精神分裂症患者稳态血药浓度的影响。方法选取使用奥氮平治疗2周以上的精神分裂症患者36例,按不同剂量阿立哌唑(5,10,15 mg/d)随机分为3组。通过自身对照法考察3组治疗前与治疗后第7天奥氮平血药浓度的变化。结果与合并阿立哌唑前相比,合并不同剂量阿立哌唑(5,10,15 mg/d)治疗后第7天,3组患者的奥氮平血药浓度均升高,且差异有统计学意义(P <0.05)。结论联用阿立哌唑治疗精神分裂症可增加血浆中奥氮平的血药浓度,二者联用时应调整给药剂量,加强血药浓度监测,防止不良反应发生。

Objective To investigate the effect of different doses of aripiprazole on the steady state plasma concentration of olanzapine for patients with schizophrenia.Methods Thirty-six patients with schizophrenia who were treated with olanzapine for more than 2 weeks were selected and randomly divided into 3 groups according different doses of aripiprazole( 5,10,15 mg/d).The self-control method was used to investigate the blood concentration of olanzapine before and 7 d after treatment.Results Compared with before combining aripiprazole,at 7 d after combined treatment with different doses of aripiprazole( 5,10,15 mg/d),the drug plasma concentration of the 3 groups all increased,and the difference was statistically significant( P < 0.05).Conclusion The combination of aripiprazole in the treatment of schizophrenia can increase the plasma concentration of olanzapine.When the two are combined,the dose should be adjusted to monitor the blood concentration to prevent adverse reactions.