奥卡西平联合认知功能训练治疗癫痫效果及安全性分析

Efficacy and Safety of Oxcarbazepine Combined with Cognitive Function Training in the Treatment of Epilepsy

目的探讨奥卡西平联合认知功能训练治疗癫痫的临床疗效及安全性。方法选取医院2017年3月至2019年3月收治的癫痫患儿104例,随机分为观察组和对照组,各52例。两组患儿均给予认知功能训练,观察组患儿联合奥卡西平治疗。两组患儿均连续治疗6个月。结果观察组总有效率为90.38%,显著高于对照组的75.00%(P <0.05);与对照组相比,治疗第1,3,6个月后观察组患儿的癫痫发作频次均显著降低(P <0.05),治疗后观察组患儿简易精神状态量表(MMSE)评分、韦氏智力量表(FIQ)评分、青少年癫痫患者生活质量问卷(QOLIE-AD-48)评分均显著升高(P <0.05),血清同型半胱氨酸(HCY)、细胞间黏附分子-1(ICAM-1)水平均显著降低,脑源性神经营养因子(BDNF)水平显著升高(P <0.05);治疗期间,两组患儿的不良反应发生率相当(15.38%比9.62%,P> 0.05)。结论奥卡西平联合认知功能训练治疗癫痫临床疗效较好,可降低癫痫发作频次,改善患儿认知功能、智力水平、生活质量及血清生物学指标水平,且安全性好,值得临床推广。

Objective To study the application and safety of oxcarbazepine combined with cognitive training in the treatment of epilepsy.Methods A total of 104 children with epilepsy admitted to the hospital from March 2017 to March 2019 were selected and randomly divided into the observation group and control group,52 cases in each group.Both groups were given cognitive function training,and the observation group was combined with oxcarbazepine on this basis.Both groups received 6 months of continuous treatment.Results The total effective rate of the observation group was 90.38%,which was higher than 75.00% of the control group( P < 0.05).After1,3,6 months of treatment,the frequency of epileptic seizures in the observation group was significantly lower than that in the control group( P < 0.05).After treatment,the scores of the Mini Mental State Scale( MMSE),the Full-scale Intelligence Quotient( FIQ) of the Wechsler Intelligence Scale and the Quality of Life Questionnaire( QOLIE-AD-48) of the observation group were significantly higher than those of the control group( P < 0.05);the levels of serum homocysteine( HCY) and intercellular adhesion molecule-1( ICAM-1)in the observation group were significantly lower than those in the control group.Brain-derived neurotrophic factor( BDNF) level was significantly higher than that of the control group( P < 0.05).During the treatment period,the incidence of adverse reactions in the observation group and the control group had no statistically significant difference( 15.38% vs.9.62%,P > 0.05).Conclusion Oxcarbazepine combined with cognitive function training in the treatment of children with epilepsy has good effect.It can reduce the frequency of epilepsy,improve the cognitive function,intelligence level,quality of life and serum biological indicators of children with epilepsy,and the treatment safety is good,which is worthy of clinical recommendation.