儿童特应性皮炎血清25-羟维生素D的表达及其临床意义

Expression of serum 25-hydroxyvitamin D in children with atopic dermatitis and its clinical significance

目的:检测儿童特应性皮炎(AD)血清25-羟维生素D[25(OH)D]的表达,并探讨其临床意义。方法:采用电化学发光法检测52例AD患儿和46例正常儿童血清25(OH)D和总IgE表达水平,根据SCORAD评分法评估AD患儿疾病严重程度,比较两组血清25(OH)D及总IgE差异,并分析AD组血清25(OH)D及总IgE水平与SCORAD评分的相关性。结果:AD组血清25(OH)D水平低于对照组,差异有统计学意义(P<0.05);AD组血清总IgE水平高于对照组,差异有统计学意义(P<0.05);AD组血清25(OH)D与SCORAD评分之间呈负相关(P<0.05),与血清总IgE呈负相关性(P<0.05);AD组血清总IgE与SCORAD评分之间无相关性(P>0.05)。结论:AD患儿血清25-羟维生素D表达水平高于健康儿童,而且与疾病严重程度相关,提示维生素D在儿童特异性皮炎发病中起到重要作用。

Objective To detect the expression of serum 25-hydroxyvitamin D in children with atopic dermatitis(AD)and explore its clinical significance.Method The serum levels of 25(OH)D and total IgE in 52 children with AD and 46 normal children were detected by electrochemiluminescence.The severity of AD was assessed by SCORAD score.The differences of serum 25(OH)D and total IgE between the two groups were compared.The correlation between serum 25(OH)D and total IgE levels and SCORAD score in AD group was analyzed.Results Serum 25(OH)D level in AD group was lower than that in control group(P<0.05),and total IgE level in AD group was higher than that in control group(P<0.05).Serum 25(OH)D in AD group was negatively correlated with SCORAD score(P<0.05),and negatively correlated with total serum IgE(P<0.05);there was no correlation between total serum IgE and SCORAD score in AD group(P>0.05).Conclusion The expression level of serum 25-hydroxyvitamin D in children with AD is higher than that in healthy children,and it is related to the severity of the disease,suggesting that vitamin D plays an important role in the pathogenesis of children with atopic dermatitis.