乙醛脱氢酶2基因多态性在冠心病患者传统危险因素之间的相关性研究

Association of ALDH2 Gene Polymorphism and traditional risk factors of coronary heart disease patients

目的研究乙醛脱氢酶2(ALDH2)基因多态性在冠心病患者传统危险因素之间的相关性。方法选取新疆医科大学第一附属医院于2019年5月-2020年5月收治的357例冠心病患者作为试验组,选取同期347例非冠心病患者作为对照组。采用凝胶电泳及PCR扩增技术检测两组受试对象基因多态性,并检测血脂、凝血功能等生化指标,分析乙醛脱氢酶2基因多态性与冠心病患者传统危险因素的相关性。结果两组受试对象在乙醛脱氢酶2基因Lys504Lys、Glu504Lys与Glu504Glu表型的分布差异无统计学意义(P=0.495)。冠心病患者乙醛脱氢酶2基因不同表型和已纳入的传统危险因素指标之间无紧密关联。结论乙醛脱氢酶2基因Glu504Glu、Lys504Lys、Glu504Lys表型与冠心病传统危险因素之间无明显相关性。

Objective To investigate the relationship betweenthe alcohol dehydrogenase2(ALDH2)genepolymorphism and the traditional risk factors of coronary heart disease(CHD).Methods A total of 357 patients with CHD and 347 patients without CHD who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from 2019 to 2020 were selected.All subjects were tested for theALDH2 genotype,and the relationship between the ALDH2 Gene Polymorphism and traditional risk factors of CHD was analyzed.Results There was no significant difference in the distribution of ALDH2 Gene Glu504glu,Lys504lys and Glu504Lys phenotypes between the CHD group and non CHD group(P=0.495).There was no correlation between the ALDH2 Gene phenotype and traditional risk factors.Conclusion The phe-notypes of ALDH2 Gene Glu504glu,Lys504lys and Glu504Lys have no significant correlation with the traditional risk factors of CHD.