199例体检人群血清hs-CRP水平与慢性牙周炎及高血压的相关研究

Correlation between serum hs-CPR level and chronic periodontitis and hypertension of 199 physical examinees

目的研究199例体检人群慢性牙周炎伴高血压患者的牙周状况、血压指数及血清超敏-C反应蛋白(hs-CRP)的水平,探讨成人慢性牙周炎及高血压与hs-CRP之间的关系。方法以2018年7月199例体检人群为研究对象,根据是否患有牙周炎和高血压,将研究对象分为健康对照组、慢性牙周炎组、高血压组和慢性牙周炎+高血压组,取血液样本,采用hs-CRP试剂盒测定血清hs-CRP水平,单因素方差分析4组间hs-CRP水平的差异性,Pearson相关性检验分析hs-CRP水平与慢性牙周炎和高血压的相关性,Logistic回归分析慢性牙周炎和高血压的危险因素。结果与HC组、CP组和HTN组比较,CP+HTN组的探诊深度、结石指数(Calculus Index,CI)、hs-CRP水平、收缩压、舒张压均升高,差异有统计学意义(P<0.05);hs-CRP水平与PD、附着丧失、CI、龈沟出血指数(Sulcular Bleeding Index,SBI)、慢性牙周炎、高血压、收缩压和舒张压均成正相关,相关系数(r)分别是0.255、0.199、0.364、0.364、0.332、0.399、0.280、0.184。Logistic回归分析显示:慢性牙周炎的危险因素分别是肉类食用量{OR=0.830,95%CI(0.706,0.977),P=0.025},血清hs-CRP水平{OR=2.027,95%CI(1.505,2.730,P=0.001)},文化水平(小学及以下){OR=-0.315,95%CI(0.151,0.658),P=0.002}。HTN的危险因素是hs-CRP的水平{OR=2.056,95%CI(1.562,2.708),P=0.001}。结论成人血清hs-CRP水平与慢性牙周炎和高血压相关,hs-CRP水平是慢性牙周炎和高血压的共同危险因素。

Objective To study the periodontal status,blood pressure index andserum hypersensitivity-CRP(hs-CRP)level of Uyghur adults with chronic periodontitis with hypertension in Moyu County of Xinjiang,and to explore the relationship between the chronic periodontitis and hypertension and hs-CRP in Uyghur adults in Moyu County.Methods In July 2018199 Uyghur physical examination population in Moyu County of Xinjiang were selected as the research object.According to whether they had periodontitis and hypertension,the research objects were divided into healthy control(HC)group,chronic periodontitis(CP)group,hypertension(HTN)group and chronic periodontitis+hypertension(CP+HTN)group.The serum hs-CRP level was measured with hs-CRP kit.The difference of hs-CRP levels among the four groups was analyzed by one-way ANOVA.Pearson correlation test was used to analyze the correlation between the hs-CRP levels and chronic periodontitis and hypertension.Logistic regression was used to analyze the risk factors of chronic periodontitis and hypertension.Results Compared with the HC group,CP Group and HTN group,the detection depth,calculus index(CI),hs-CRP level,systolic blood pressure and diastolic blood pressure in the CP+HTN group were significantly higher than those in the HC group(P<0.05);hs-CRP level was significantly higher than that in the CP+HTN group(P<0.05),SBI,chronic periodontitis,hypertension,systolic blood pressure and diastolic blood pressure were positively correlated,and the correlation coefficients(R)were 0.255,0.199,0.364,0.364,0.332,0.399,0.280 and 0.184,respectively.Logistic regression analysis showed that the risk factors of the chronic periodontitis were meat consumption{OR=0.830,95%CI(0.706,0.977),P=0.025},serum hs-CRP level{OR=2.027,95%CI(1.505,2.730,P=0.001)},education level(primary school and below){OR=-0.315,95%CI(0.151,0.658),P=0.002}.The risk factor of HTN was hs-CRP level{OR=2.056,95%CI(1.562,2.708),P=0.001}.Conclusion The serum hs-CRP level of Uyghur minority in Moyu County of Xinjiang is related to chronic periodontitis and hypertension,hs-CRP is a common risk factor for the chronic periodontitis and hypertension.