广州市某机构2013-2017年育龄期妇女丙型肝炎病毒感染情况分析

Analysis of the infection situation of hepatitis c virus( HCV) among childbearing age women in an institution of Guangzhou,2013-2017

目的了解广州市部分地区育龄期妇女抗-HCV阳性检出率及其流行病学特征,为制定防治措施提供依据。方法以2013-2017年在广东省妇幼保健院就诊的191 494例育龄期妇女为研究对象,采用酶联免疫法检测其血清抗-HCV。结果总共筛查出抗-HCV抗体阳性者433例,阳性检出率为0.23%;15~岁组、20~岁组、25~岁组、30~岁组、35~岁组、40~岁组及45~49岁组阳性检出率分别为0.19%、0.15%、0.14%、0.22%、0.41%、0.48%和0.62%,不同年龄段育龄期妇女抗-HCV抗体阳性检出率比较,差异有统计学意义(χ~2=121.4,P <0.01);随着年龄增长,抗-HCV抗体阳性检出率显著增加(趋势χ~2=95.35,P <0.01);2013-2017年检出率维持在0.23%上下波动,不同年份、不同季节间阳性检出率差异无统计学意义。结论广州市部分地区育龄期妇女丙型肝炎病毒阳性检出率保持稳定,年龄是其影响因素,应结合流行病学特征采取综合性防控措施。

Objective To analyze the positive detection rate of anti-HCV and its Epidemiological characteristics among childbearing age women,so as to provide a basis for the development of prevention and treatment measures. Methods A total of191494 women in Guangdong women and children hospital from 2013 to 2017 were selected as the research objects. Anti-HCV was detected by Enzyme-linked immunosorbent experiment. Results A total of 433 cases of anti-HCV antibody positive were detected and the detection rate was 0. 23%. The rates of positive anti-HCV in women at age of 16-19,20-24,25-29,30-34,35-39,40-44 and 45-49 years groups was 0. 19%,0. 15%,0. 14%,0. 22%,0. 41%,0. 48% and 0. 62%,respectively. There was statistically significant difference among the different age groups( χ~2= 121. 4,P < 0. 01). With the increase of age,the positive rate increased significantly( Trend χ~2= 95. 35,P < 0. 01). The detection rate remained at around 0. 23% from 2013 to 2017. There were no significant differences in the positive rate among the different years and seasons( P > 0. 05). Conclusion The positive detection rate of antiHCV among childbearing age women in Guangzhou maintained a stable state. Age is the influencing factor. The comprehensive prevention and control measures should be taken in combination with epidemiological characteristics.