南宁地区儿童呼吸道腺病毒感染的流行病学研究

Epidemiological study of adenovirus infection in children’s respiratory tract in Nanning

目的了解南宁地区儿童呼吸道腺病毒(Adenovirus,ADV)感染流行病学特征。方法收集2017年7月-2019年7月在广西壮族自治区妇幼保健院就诊的呼吸道感染患儿32 234例,采用间接免疫荧光法对患儿静脉血标本进行ADV检测,分析ADV感染特征和临床诊断特点。结果①32 234例受检患儿中ADV检出阳性率为1.82%,男、女性分别为1.76%、1.92%(χ2=1.04,P=0.308),0~<6个月、6个月~<2岁、2岁~<5岁、5岁~<14岁分别为0.49%、2.63%、2.28%和0.96%(χ2=29.937,P <0.05)。②不同季节春、夏、秋、冬ADV阳性率分别为1.8%、2.34%、1.24%、1.99%(χ2=145.5,P <0.05)。③587例ADV检出阳性病例中,诊断为肺炎274例,支气管炎104例,急性咽喉炎43例,急性扁桃体炎15例,急性上呼吸道感染9例,其他非呼吸道感染诊断142例。结论腺病毒是南宁地区儿童呼吸道感染的重要病原之一,了解南宁地区儿童呼吸道腺病毒感染的流行病学特征对本地区儿童呼吸道疾病的防治有重要意义。

Objective To investigate the epidemiological characteristics of children respiratory Adenovirus( ADV) infection in Nanning. Methods ADV was detected by indirect immunofluorescence method in the serum from 32 234 children with respiratory tract infection from July 2017 to July 2019. The clinical diagnostic information was collected and analyzed. Results ①The positive rate of ADV was 1. 82%( 587/32 234) among 32 234 children. The positive rate of boys and girls was 1. 76% and 1. 92%,respectively( P = 0. 308). The positive detection rate in 0-< 6 months,6 months-< 2 years old,2 years old-< 5 years old,5 years old-< 14 years old was 0. 49%,2. 63%,2. 28% and 0. 96%,respectively( P < 0. 05) . ② In Spring,Summer,Autumn and Winter,the positive rate of ADV was1. 8%,2. 34%,1. 24% and 1. 99%,respectively( P < 0. 05) . ③Among 587 positive ADV cases,274 were diagnosed as pneumonia,104 were bronchitis,43 were acute pharyngolaryngitis,15 were acute tonsillitis,9 were acute upper respiratory tract infection and 142 were other non-respiratory tract infection. Conclusion ADV is one of the important pathogens of children ’s respiratory tract infection in Nanning. Understanding the epidemiological characteristics of children ’s respiratory tract ADV infection in Nanning is of great significance to the prevention and treatment of children’s respiratory tract diseases in this region.