血清维生素A、D的水平对脑瘫高危儿体格与神经发育的影响及早期干预疗效分析

Effect of serum vitamin AD level on physical and neurological development of high risk children with cerebral palsy and its early intervention

目的探讨维生素A、D水平对脑瘫高危儿体格及神经发育的影响及早期干预疗效。方法选择2017年4月-2019年4月在山东省济宁市第一人民医院就诊进行体格检查的0~12月龄婴儿,根据出生时伴有早产、低出生体重、窒息、缺血缺氧性脑病、颅内出血等危险因素选为高危儿组。选择该院足月分娩的0~12月龄健康婴幼儿为健康婴儿组。根据家属治疗意愿将高危儿组分为维生素A、D干预组和对照组。治疗3个月后,比较不同组别高危儿体格和神经发育评估结果。结果共计完成随访婴儿1500例,其中高危儿组1000例,健康婴儿组500例;高危儿组分为干预组561例和非干预组439例;不同组别婴幼儿性别、分娩方式、家庭经济水平、高危因素等资料对比差异无统计学意义(P> 0.05);高危儿组血清维生素A、D含量均低于健康婴儿组,体格和神经发育评估发育商(DQ评分)低于健康婴儿组;高危儿非干预组发育商(DQ评分)及体格发育均低于干预组,差异有统计学意义(P <0.05)。结论脑瘫高危儿血清维生素A、D含量低于健康婴儿,早期给予足够剂量维生素A、D补充,能够改善脑瘫高危儿体格与神经发育。

Objective To explore the effect of vitamin AD on physical and neurological development of high risk children with cerebral palsy and the early intervention effect. Method The infants aged 0-12 months from April 2017 to October 2019 were selected for physical examination in our hospital the high risk group was selected according to the risk factors of premature delivery,low birth weight,asphyxia,hypoxic-ischemic encephalopathy and intracranial hemorrhage. The healthy infants of 0-12 months were selected as the group of healthy infants. The high-risk infants were divided into vitamin AD intervention group and control group according to the treatment intention of family members. After 3 months of treatment,the physical and neurodevelopmental assessment of high risk infants in different groups were compared. Results A total of 1500 infants were followed up,including 1000 high risk infants,500 healthy infants,561 high risk infants and 439 non-intervention infants There was no significant difference in the data of sex,mode of delivery,family economic level and high risk factors among different groups( P > 0. 05),and the content of serum vitamin AD in High Risk Group was lower than that in healthy group The developmental quotient( DQ) of physical and neurodevelopmental assessment was lower than that of healthy infants,and the developmental quotient( DQ) and physical development of high risk infants in nonintervention group were lower than that of intervention group( P < 0. 05). Conclusion The content of serum vitamin AD in high risk infants with cerebral palsy is lower than that in healthy infants. Sufficient dose of vitamin AD supplementation in early stage can improve the physical and neurological development of high risk infants.