Mucin 5AC蛋白对胃息肉恶变患者病情发生发展的影响

Effct of Mucin 5AC Protein on the Occurrence and Development of Malignant Gastric Polyps

[目的]探讨胃息肉组织Mucin 5AC蛋白的表达及临床意义。[方法]选取在本院治疗的胃息肉患者160例,同时选取正常胃黏膜组织87例,胃癌组织90例作为对照,采用免疫组化染色法检测其Mucin 5 AC蛋白表达水平。[结果]胃息肉Mucin 5AC蛋白阳性表达率为64.38%(103/160),明显高于胃癌组织的41.11(37/90,P<0.05),但低于正常胃组织的87.0%(87/100),且各组之间相比较差异均有显著性(P<0.05)。增生性息肉组织Mucin 5AC蛋白阳性表达率为71.43%(70/98),明显高于腺瘤性息肉的53.23%(33/62),且两者相比较差异有显著性(P<0.05)。不同性别、年龄、大小、部位胃息肉组织的Mucin 5AC蛋白阳性表达率相比较差异均无显著性(P>0.05)。[结论]Mucin 5AC蛋白可能在胃息肉恶变过程中表达下调,其结果值得进一步研究。

[Objective]To investigate the expression of Mucin 5AC protein in gastric polyps and its elinical sig-nificance.[Methods]A total of 160 patients with gastric polyps treated in our hospital from January 2017 t0 Janu-ary 2018 were selected,meanwhile 87 normal gastric mucosa tissues and 90 gastric cancer tissues were enrolled as controls.Mucin 5AC protein expression was detected by immunchistochemical staining.[Results]The positive ex-pression rate of Mucin 5AC protein in gastric polyps was 64.38%(103/160),which was significantly higher than that in gastric cancer(41.11%,P<0.05).but lower than that in normal gastric tissues(87%,P<0.05).The positive expression rate of Mucin 5AC protein in proliferative polyps was 71.43%,which was significantly higher than that in adenomatous polyps(53.23%.P<0.05);There were no significant difference in terms of the positive expression rate of Mucin 5AC protein in different age.gender.size and location of gastric polyps(P>0.05).[Conclusion]Mucin 5AC protein may be down regulated during malignant transformation of gast rie polyps.which deserves further study.