奥氮平与利培酮对精神分裂症患者血清BDNF、NGF、IL-6水平的影响及临床应用效果比较

Effcts of Olanzapine and Risperidone on Serum Levels of BDNF,NGF and IL-6 in Patients with Schizophrenia

[目的]比较奥氮平与利培酮对精神分裂症患者血清脑源性神经营养因子(BDNF)、神经生长因子(NGF)、白介素-6(IL-6)水平的影响及临床应用效果。[方法]前瞻性选取2018年3月至2020年6月本院收治的72例精神分裂症患者为研究对象,采用随机数表法将其分为利培酮组与奥氮平组,每组各36例。分别给予利培酮、奥氮平治疗.持续6个月。比较两组患者干预前后血清BDNF、NGF、IL-6水平,并比较阳性阴性症状量表(PANSS)评分以及不良反应发生率。[结果]治疗1、3、6个月,两组患者PANSS评分均显著低于治疗前,差异有统计学意义(P<0.05);治疗6个月,奥氮平组PANSS评分显著高于利培酮组,差并有统计学意义(P<0.05)。治疗1、3、6个月,两组恋者血清BDNF、NGF水平高于治疗前,血清IL-6水平低于治疗前,差异有统计学意义(P<0.05)。治疗3、6个月,奥氮平组血清BDNF水平显著高于利培酮组,治疗6个月时血清NGF水平高于利培酮组,血清IL-6水平低于利培酮组,差异均有统计学意义(均P<0.05)。奥氮平组患者锥体外系的发生率显著低于利培酮组。差异有统计学意义(P<0.05)。[结论]奥氮平能显著降低精神.分裂症患者的血清BDNF、NGF、L-6水平,可较好缓解患者的精神分裂症状,长期应用败果优于利培酮,且安全性更高。

[Objective]To compare the efeet of olanzapine and risperidone on serum brain derived neuro-trophic factor(BDNF),nerve growth factor(NGF),interleukin-6(IL-6)levels and elinical application effect in patients with schizophrenia.[Methods]Seventy-two patients with schizophrenics admitted to our hospital from March 2016 to September 2018 were enrolled for the study and randomly divided into risperidone group(n=36)and olanzapine group(n=36),and they were treated with risperidone and olanzapine respectively for 6 months.The serum levels of BDNF,NGF,IL-6,the score of positive and negative symptom scale(PANSS)and the incidence of adverse reactions were compared before and after intervention between two groups.[Re-sults]There were no significant differences in baseline data.total score of PANSS,serum levels of BDNF,NGF and IL-6 between two groups(P>0.05).For intra-comparison,the PANSS total score and serum level of IL-6 al 1,3,6 months after intervention in 1wo groups were significantly lower than that before interven-tion,and serum levels of BDNF and NGF at 1,3,6 months after intervention were significantly higher than that before intervention(P<0.05).For inter-comparison,the PANSS total score and serum level of NGF at 6 months after intervention in olanzapine group were significantly higher than that in the risperidone group at the same time,the serum level of BDNF at 3 and 6 months after intervention in the olanzapine group was sig-nificantly higher than that of the risperidone group at the same time,and the serum level of IL-6 at 6 months after intervention in the olanzapine group was significantly lower than that in the risperidone group at the same time(P<0.05).The incidence of extrapyramidal system in the olanzapine group was significantly lower than that in the risperidone group(P<0.05).and there were no significant differences in other adverse reactions including headache,dizziness,abnormal sleep,increased body mass and dry mouth between two groups(P>0.05).[Conclusion]Olanzapine can significantly reduce the serum levels of BDNF,NGF and L-6 in schizo-phrenic patien1s.Olanzapine can better alleviate the symptoms of schizophrenia.The long-term effecl of olanzapine is better than risperidone.and the safety is higher.