脑白质高信号的病理生理学机制

Pathophysiological mechanism of white matter hyperintensities

脑白质高信号(white matter hyperintensities, WMHs)是脑小血管病的MRI表型之一,在老年人中多见,并且与认知损害及步态障碍等临床表现密切相关,但其病理学机制目前尚不明确。文章从低灌注、血脑屏障破坏、氧化应激、炎症和遗传等多个方面阐述了WMHs的可能病理生理学机制。

White matter hyperintensities(WMHs)are one of the MRI markers of cerebral small vessel disease,which are more common in the elderly,and are closely associated with the clinical manifestations such as cognitive impairment and gait disorder,however,the pathophysiological mechanism is currently unclear.This article expounds the possible pathophysiological mechanisms of WMHs from many aspects,such as hypoperfusion,blood-brain barrier destruction,oxidative stress,inflammation,and genetics.