芪术润肠汤治疗习惯性便秘的临床研究

Clinical study of Qizhu Runchang Decoction on habitual constipation

目的探讨芪术润肠汤对习惯性便秘的临床疗效。方法选取2017年11月至2018年11月符合习惯性便秘诊断标准的患者120例,按随机数表法分为对照组和观察组,每组各60例;对照组服用麻仁丸,观察组服用芪术润肠汤汤剂,观察两组用药后的临床疗效及不良反应。结果治疗前,两组排便率比较,差异无统计学意义(P>0.05);治疗后,观察组排便时间间隔总有效率为90.00%,对照组为63.33%,差异有统计学意义(P<0.05);治疗后观察组粪便干结总有效率为93.33%,对照组为55.00%(P<0.05);对照组与观察组治疗前排便费力程度比较,差异无统计学意义(P>0.05),治疗后观察组治疗总有效率为91.67%,对照组58.33%,差异有统计学意义(P<0.05);治疗后观察组口干、腹痛、腹胀及纳差控制率和总有效率均优于对照组,差异有统计学意义(P<0.05)。依据中医症候疗效评价标准:观察组痊愈19例、显效28例、有效11例,总有效率为96.67%,对照组痊愈3例、显效22例、有效26例,总有效率为85.00%,差异有统计学意义(P<0.05)。结论中医辩证为脾虚气弱、阴虚肠燥证型的习惯性便秘采用芪术润肠汤治疗效果明显,值得临床推广使用。

Objective Explore the clinical effect of Qizhu Runchang Decoction on habitual constipation.Methods Selected from November 2017 to November 2018,120 patients with habitual constipation in the hospital were randomly divided into control group and observation group according to the random number table method,with 60 cases in each group.The control group took Maren pills and the observation group took Qizhu Runchang Decoction,then observe the clinical efficacy and other adverse reactions of the two groups after medication.Results Before treatment,there was no statistically significant difference in defecation rate and degree of defecation effort between the two groups(P>0.05).After treatment,the total effective rate of defecation interval in the observation group was 90.00%,and that of the control group was 63.33%(P<0.05);the total effective rate of dry stool was 93.33%in the observation group and 55.00%in the control group(P<0.05);the total effective rate of treatment was 91.67%,and that of the control group was 58.33%(P<0.05);the control rate and total effective rate of dry mouth,abdominal pain,abdominal distension and anorexia in the observation group were better than those in the control group(P<0.05).According to the evaluation criteria of TCM symptoms:19 cases were cured in the observation group,28 cases were markedly effective,11 cases were effective,the total effective rate was 96.67%,and the control group was cured 3 cases,22 cases markedly effective,and 26 effective cases,with a total effective rate of 85.00%,statistically significant(P<0.05).Conclusion The traditional Chinese medicine dialectics is habitual constipation with spleen deficiency,qi deficiency,yin deficiency and intestinal dryness.The treatment effect of Qishu Runchang Decoction is obvious,which is worthy of clinical promotion.