注射用温敏凝胶在肿瘤局部治疗中的应用

Application of Injectable Thermosensitive Gels in Local Cancer Therapy

注射用温敏凝胶作为新型局部药物递送系统,具有温敏性相变、精准递送药物、可控释药、生物相容性好等特点,已成为近年来肿瘤治疗新型载体研究的热点之一。本文对注射用温敏凝胶的优势、常用凝胶材料进行介绍,综述近年来注射用温敏凝胶作为药物递送系统在肿瘤局部治疗中的应用现状,为注射用温敏凝胶的研发及临床应用提供参考。

Injectable thermosensitive gels have gained increasing attention in recent years as novel local drug delivery system for antineoplastics,which have a number of advantages including phase transition?with temperature change,precise delivery of drug,sustained-and controlled-release of drugs and excellent biocompatibility.In this review,the advantages,commonly used materials and recent applications of injectable thermosensitive gels in local cancer therapy are summarized,which can provide some references for the development and clinical application of injectable thermosensitive gels.