督灸联合柴胡舒肝丸对气郁质失眠患者体质偏颇状态、5-羟色胺(5-HT)及多巴胺(DA)影响的临床观察

Clinical Observation on the Effect of Du Moxibustion Combined with Chaihu Shugan Pill on Physique Bias,5-hydroxytryptamine(5-HT)and Dopamine(DA)in Patients with Qi Depression Insomnia

目的探讨督灸联合柴胡舒肝丸对气郁质失眠患者体质偏颇状态、5-HT及DA的影响.方法80例气郁质失眠患者随机分为治疗组、对照组.治疗组采用督灸联合柴胡舒肝丸法治疗,督灸每10 d治疗一次,3次为一个疗程,共治疗2个疗程.柴胡舒肝丸每次1丸,早晚各1次,30 d为一个疗程,共服用2个疗程.对照组口服佐匹克隆,每次1片(7.5 g),睡前口服,30 d为一个疗程,共服用2个疗程.结果治疗结束后,治疗组总有效率92.50%,高于对照组总有效率82.50%.治疗组气郁体质转化分较治疗前显著下降(P<0.05),对照组气郁质转化分变化无统计学差异(P>0.05).2组受试者5-HT水平较治疗前均显著升高、DA水平较治疗前均显著降低,差异具有统计学意义(P<0.05).治疗后组间比较,治疗组5-HT含量显著高于对照组,DA含量显著低于对照组,差异均具有统计学意义(P<0.05).结论督灸联合柴胡舒肝丸通过调节神经调节因子5-HT和DA含量对气郁质失眠起治疗作用,疗效优于西药治疗;督灸联合柴胡舒肝丸还能纠正患者气郁体质偏颇状态,可作为中医绿色疗法推广.

Objective To explore the effect of du moxibustion combined with Chaihu Shugan pill on physique bias,5-HT and DA in patients with qi depression and insomnia.Methods 80 patients with insomnia due to qi depression were randomly divided into treatment group and control group.Subjects in treatment group were treated with du moxibustion combined with Chaihu Shugan pill.Du moxibustion was treated once every 10 days,3 times a course of treatment,a total of 2 courses of treatment.Chaihu shugan pills 1 pill each time,once in the morning and evening,30 days a course of treatment,a total of two courses of treatment.The control group took zopiclone orally,1 tablet(7.5 g)each time,before going to bed,a course of treatment for 30 days,a total of two courses of treatment.Results After treatment,the total effective rate was 92.5%in the treatment group and 82.5%in the control group.The physical transformation score of qi depression in the treatment group was significantly lower than that before treatment(P<0.05),but there was no significant difference in the control group(P>0.05).The level of 5-HT in the two groups was significantly higher than that before treatment,while the level of DA was significantly lower than that before treatment,and the difference was statistically significant(P<0.05).After treatment,the content of 5-HT in the treatment group was significantly higher than that in the control group,while the content of DA in the treatment group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Du moxibustion combined with Chaihu Shugan pills can treat insomnia of qi depression by regulating the contents of 5-HT and DA,and the curative effect is better than that of western medicine.Du moxibustion combined with Chaihu Shugan pills can also correct the biased state of qi depression and physique,which can be promoted as a green therapy of traditional Chinese medicine.