自拟安胎丸对肾气虚型早期先兆流产患者血清P、β-HCG水平及保胎效果影响

Effect of Self-made Antai Pill on Serum Progesterone, β-HCG Levels and Fetal Protection in Patients with Early Threatened Abortion with Kidney Qi Deficiency

目的探讨自拟安胎丸对肾气虚型早期先兆流产患者血清孕酮(P)、绒毛膜促性腺激素(β-HCG)水平及保胎效果影响。方法选取2016年4月—2019年4月治疗的肾气虚型早期先兆流产患者,共60例,按照随机数字表法分为观察组(30例)与对照组(30例)。对照组采用地屈孕酮治疗,观察组在对照组的基础上加用自拟安胎丸,均治疗2周。比较2组治疗后保胎成功率及不良反应发生率;比较2组治疗前后血清P、β-HCG的水平及中医各项证候积分变化。结果与治疗前比,治疗后,2组阴道流血时间、阴道流血量、下腹部疼痛或坠胀、腰膝酸软积分均降低,且观察组显著低于对照组(P<0.05);2组血清P、β-HCG水平均升高,且观察组显著高于对照组(P<0.05)。治疗后,观察组保胎成功率(90.00%)显著高于对照组(66.67%)(P<0.05)。观察组不良反应总发生率(10.00%)与对照组(30.00%)比较无显著差异(P>0.05)。结论自拟安胎丸可提高肾气虚型早期先兆流产患者血清P、β-HCG水平,有助于缓解临床病症,保胎效果优于口服地屈孕酮治疗,且安全性良好,无毒副作用。

Objective To investigate the effect of self-made Antai pills on serum progesterone(P), chorionic gonadotropin(β-HCG) levels and the effect of fetal protection in patients with early threatened abortion with kidney qi deficiency. Methods A total of 60 patients with early threatened abortion of kidney qi deficiency that were treated in our hospital from April 2016 to April 2019 were selected. They were divided into the observation group(n=30) and the control group(n=30) according to the random number table. The control group was treated with diquprogesterone, and the observation group was treated with self-made Antai pill on the basis of the control group for 2 weeks. The success rate and incidence of adverse reactions after treatment were compared between the two groups, and the levels of serum P and β-HCG and the scores of TCM symptoms before and after treatment were compared. Results Compared with the ratio before treatment, vaginal bleeding time, vaginal bleeding volume, lower abdominal pain or distension, and lumbar and knee acid-soft score were all reduced in the two groups, and the observation group was significantly lower than the control group(P<0.05). Serum P and β-HCG levels in both groups were increased, and those in the observation group were significantly higher than those in the control group(P<0.05). After treatment, the success rate of fetal preservation in the observation group(90.00%) was significantly higher than that in the control group(66.67%)(P<0.05), and the overall incidence of adverse reactions in the observation group(10.00%) was not significantly different from that in the control group(30.00%)(P>0.05). Conclusion The self-made Antai pill can improve the serum levels of P and β-HCG in patients with early threatened abortion with kidney qi deficiency, which is helpful to alleviate the clinical symptoms. The effect of fetal protection is better than that of oral diquprogesterone treatment, which is safe and has no toxic side effects.