炎性小体在皮肤肿瘤中的研究进展

Role of inflammasomes in skin tumors

炎性小体是一种细胞内多蛋白复合物,是固有免疫应答的组成部分。炎性小体的功能异常可以导致机体免疫失衡,并与许多疾病密切相关。研究表明,炎性小体与基底细胞癌、鳞状细胞癌、Kaposi肉瘤及恶性黑素瘤等皮肤肿瘤有一定相关性,提示炎性小体异常活化造成的持续炎症反应及免疫应答失衡是皮肤肿瘤发生、发展、侵袭及转移的重要环节。本文概述炎性小体在皮肤肿瘤发病机理中的研究进展。

Inflammasomes are a kind of intracellular multiprotein complex that comprises a part of the innate immune response.Inflammasome function abnormalities can lead to immune imbalance and have been linked to an increasing number of diseases.Researches have shown that inflammasomes are associated with some skin tumors including basal cell carcinoma,squamous cell carcinoma,Kaposi′s sarcoma and malignant melanoma,implicating that persistent inflammatory response and immune imbalance caused by abnormal activation of inflammasomes play a crucial role in tumor occurrence,development,invasion and metastasis.This review summarizes research advances in the role of inflammasomes in the pathogenesis of skin tumors.