分子影像学检测结直肠癌免疫微环境

Molecular imaging to detect the immune microenvironment of colorectal cancer

结直肠癌是常见恶性肿瘤,免疫疗法对微卫星不稳定和常规化疗难以治疗的结直肠癌有效。了解肿瘤免疫微环境(TIME)有助于提高免疫治疗反应。分子成像可在解剖学和分子水平上实现细胞和亚细胞过程可视化,并加以表征和量化。对TIME细胞组成进行显像有助于理解肿瘤动态发展过程,发现并阐明肿瘤致病过程的分子机制,协助开发更有效的癌症治疗方法以及通过识别生物标志物准确预测不同治疗反应。本文针对分子影像学检测结直肠癌免疫微环境进展进行综述。

Colorectal cancer is common malignant tumor.Immunotherapy is effective for patients with microsatellite instability and difficulty to treat with conventional chemotherapy.Understanding of tumor immune microenvironment(TIME)will help to improve the response to immunotherapy.Molecular imaging can visualize,characterize and quantify cellular and subcellular processes at the anatomical and molecular levels.Imaging of cell components at TIME can help to understand the dynamic development process of tumor,discover and clarify the molecular mechanism in the pathogenesis of tumor,therefore being assist for the development of effective treatment methods and accurately and effectively prediction of treatment response through identification of biomarkers.The advances in molecular imaging of TIME of colorectal cancer were reviewed in this article.