肠道黏膜岩藻糖基化与炎症性肠病研究进展

Fucosylation in the intestinal mucosa and inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明、异常免疫介导的肠道慢性及复发性炎症性疾病.肠道黏膜岩藻糖基化是在岩藻糖基转移酶的调控下,将岩藻糖转移到肠道黏膜蛋白质侧链上形成岩藻糖苷键的过程.肠道黏膜岩藻糖基化在IBD中的作用机制尚未完全探明,本文就肠道黏膜岩藻糖基化与IBD研究进展作一综述.

Inflammatory bowel disease(IBD)is an unexplained,abnormal immune mediated chronic and recurrent inflammatory disorder of the intestine.Fucosylation in the intestinal mucosal is the process of transferring fucose to intestinal mucosal protein side chains under the control of fucosyltransferases to form fucosyl bonds.The mechanism of fucosylation in the intestinal mucosa in IBD has not been fully proved.In this paper,we will review the progress in understanding the relationship between fucosylation in the intestinal mucosa and IBD.