沙库巴曲缬沙坦对急性心肌梗死急诊冠脉介入术后心功能的影响

Effect of sakubatrovalsartan on cardiac function after emergency percutaneous coronary intervention in patients with acute myocardial infarction

目的分析沙库巴曲缬沙坦对急性心肌梗死急诊经冠脉介入(PCI)术后心功能的影响。方法收集2017年5月至2019年5月需进行经皮冠状动脉介入治疗的100例急性心肌梗死患者作为本次研究对象,并随机分为观察组(n=50)与对照组(n=50)。其中对照组给予依那普利进行治疗,观察组给予沙库巴曲缬沙坦进行治疗。比较两组患者临床疗效及PCI术前、术后4 h、7 d心电图变化情况,同时比较患者术后即刻、术后6个月血清N-末端B型利钠肽前体(NT-proBNP)、左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)变化情况及术后6个月不良事件。结果观察组患者术后心功能改善情况明显优于对照组(96.00%vs 84.00%,P<0.05)。术后4 h、7 d,观察组患者心电图ST段回降均明显优于对照组(P<0.05)。术后6个月,两组LVEDV、NT-proBNP比较均明显降低,但LVEF明显升高(P<0.05),且观察组LVEDV、NT-proBNP明显低于对照组,LVEF明显高于对照组(P<0.05)。观察组患者术后6个月不良事件总发生率(6.00%)明显低于对照组(24.00%)(P<0.05)。结论沙库巴曲缬沙坦治疗能够显著提高急性心肌梗死急诊经冠脉介入治疗患者的临床疗效,有效改善患者术后心功能,且降低术后不良事件发生情况,长期使用其临床效果较好。

Objective To investigate the effect of sakubatrevalsartan on cardiac function after emergency percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 100 AMI patients receiving PCI from May 2017 to May 2019 were selected and randomly divided into the observation group(n=50)and the control group(n=50).Enalapril was used in control group,and sakubatrevalsartan was given in observation group.The clinical efficacy and ECG changes before PCI,4 h and 7 d after PCI were compared between two groups.The changes of serum N-terminal B-type natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left ventricular end diastolic volume(LVEDV)immediately after operation and 6 months after operation,and adverse events during 6 months after PCI were observed and compared between two groups.Results After PCI,the cardiac function in observation group was significantly better than that in control group(96.00%vs 84.00%,P<0.05).At 4 h and 7 d after operation,the level of ST segment of ECG in observation group was significantly lower than that in control group(P<0.05).At 6 months after operation,LVEDV and NT-proBNP significantly decreased,and LVEF significantly increased compared with those immediately after operation in two groups(all P<0.05);LVEDV and NT-proBNP in observation group were significantly lower than those in control group,and LVEF was significantly higher than that in control group(P<0.05).The total incidence of adverse events in observation group was significantly lower than that in control group(6.00%vs 24.00%,P<0.05).Conclusion Sakubatrevalsartan can obviously improve the clinical effect of AMI patients treated by PCI and postoperative cardiac function,reduce the incidence of adverse events.