自拟大黄水蛭方对糖尿病患者血脂水平的影响

Effect of self-made Dahuang Shuizhi decoction on blood lipid level in patients with diabetes mellitus

目的探讨院内自拟大黄水蛭方剂对糖尿病患者血脂水平的影响。方法选择衡水市第四人民医院老年内科2016年8月至2018年8月收治的80例糖尿病并高血脂患者,按照随机法将入选患者分为对照组(40例)和观察组(40例),对照组采用辛伐他汀进行治疗,观察组采用自拟大黄水蛭方剂进行治疗,比较两组患者临床疗效,治疗前与治疗后2周、4周的血脂水平以及不良反应。结果观察组临床总有效率(95.0%)明显高于对照组(80.0%),差异有统计学意义(χ^2=4.114,P=0.043);治疗2周及4周后,观察组三酰甘油、总胆固醇、低密度脂蛋白胆固醇明显较对照组低,高密度脂蛋白胆固醇则均较对照组高,差异有统计学意义(P<0.05);观察组不良反应发生率(2.5%)略低于对照组(10.0%),但差异无统计学意义(χ^2=1.920,P=0.166)。结论大黄水蛭方剂的降脂效果较辛伐他汀好,尤其对糖尿病患者高脂血症的治疗可获得较好疗效。

Objective To investigate the Effect of self-made Dahuang Shuizhi decoction on blood lipid level in patients with diabetes mellitus.Methods A total of 80 diabetes patients combined with hyperlipidemia who received treatment at No.4 People′s Hospital of Hengshui from August 2016 to August 2018 were selected and divided into control group and observation group randomly(n=40,each).The control group was treated with simvastatin,and the observation group was treated with self-made Dahuang Shuizhi decoction.The clinical efficacy,and adverse reactions of the two groups were compared.The blood lipid levels before,2 weeks and 4 weeks after the treatment were detected and compared.Results The clinical total effective rate of the observation group was significantly higher than that of the control group(95.0%vs 80.0%,χ^2=4.114,P=0.043).After 2 and 4 weeks of treatment,triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)in the observation group were significantly lower than those in the control group,while the high-density lipoprotein cholesterol(HDL-C)in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(2.5%vs 10.0%,χ^2=1.920,P=0.166).Conclusion The effect of self-made Dahuang Shuizhi decoction on reducing blood lipid is better than simvastatin,especially in the treatment of hyperlipidemia in diabetic patients.