小剂量拜阿司匹林肠溶片对妊娠期高血压患者24 h尿蛋白定量的影响

Effect of Low-dose Bay Aspirin Enteric-coated Tablets on 24 h Urinary Protein Quantification in Pregnant Hypertensive Patients

目的探讨小剂量拜阿司匹林肠溶片对妊娠期高血压患者24 h尿蛋白定量的影响。方法选择2018年4月至2019年5月220例妊娠期高血压患者,随机分为两组各110例,研究组采用小剂量拜阿司匹林肠溶片治疗,对照组采用大剂量拜阿司匹林肠溶片治疗。两组治疗前后测定舒张压(DBP)与收缩压(SBP)及24 h尿蛋白,记录两组的分娩方式及产后异常出血情况,记录两组胎儿围生期并发症。结果治疗后,两组的SBP水平、DBP水平、24 h尿蛋白、剖宫产率、胎儿围生期并发症发生率比较差异无统计学意义(P> 0.05),但研究组产后异常出血发生率明显低于对照组(P <0.05)。结论小剂量拜阿司匹林肠溶片能够有效降低妊娠期高血压患者的血压及24 h尿蛋白,且可降低产后异常出血风险。

Objective To investigate the eff ect of low-dose bay aspirin enteric-coated tablets on 24 h urinary protein quantifi cation in pregnant hypertensive patients.Methods A total of 220 patients with gestational hypertension from April 2018 to May 2019 were selected and randomly divided into two groups:110 patients in each group.The research group was tr eated with low-dose bay aspirin enteric-coated tablets,while the control group was treated with highdose bay aspirin enteric-coated tablets.Diastolic blood pressure(DBP),systolic blood pressure(SBP)and 24 hours urinary protein were measured before and after treatment in the two groups.The delivery mode and abnormal postpartum hemorrhage of the two groups were recorded,and the perinatal complications of the two groups were recorded.Results After treatment,there was no signifi cant diff erence in SBP level,DBP level,24-hour urine protein,cesarean section rate,and fetal perinatal complications between the two groups(P>0.05),but the incidence of abnormal postpartum hemorrhage in the study group It was signifi cantly lower than the control group(P<0.05).Conclusion Low-dose bay aspirin enteric-coated tablets can eff ectively reduce blood pressure and urinary protein at 24 hours in patients with gestational hypertension and reduce the risk of abnormal postpartum bleeding.