右美托咪定治疗急性左心衰竭患者的临床疗效及安全性

The Clinical Efficacy and Safety of Dexmedetomidine in the Treatment of Patients with Acute Left Heart Failure

目的观察分析右美托咪定治疗急性左心衰竭患者的临床疗效及安全性。方法选取我院2016年3月至2018年3月收治的98例急性左心衰竭患者,依据随机数字表法将其分成研究组与对照组,各49例。对照组患者采用常规治疗,研究组患者在对照组基础上采用右美托咪定治疗。对两组患者治疗24 h和48 h后的左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、吗啡使用量和次数进行比较。结果研究组治疗24 h后和治疗48 h后的LVEF、LVEDD均优于对照组,差异有统计学意义(P <0.05);研究组患者吗啡使用剂量及次数均少于对照组,差异有统计学意义(P <0.05)。结论与常规治疗相比,在常规治疗基础上应用右美托咪定治疗的临床效果更为显著,可在提升LVEF的同时降低LVEDD,减少吗啡使用剂量和次数。

Objective To observe and analyze the clinical effi cacy and safety of dexmedetomidine in the treatment of patients with acute left heart failure.Methods A total of 98 patients with acute left heart failure were selected from our hospital from March 2016 to March 2018.The patients were divided into study group and control group,49 cases in each group.The control group were treated with routine treatment,while the study group were treated with dexmetomide on the basis of the control group.The left ventricular ejection fractions(LVEF),left ventricular end-diastolic diameter(LVEDD),morphine dosage and frequency of the patients in the study group were compared with those in the control group after 24 hours and 48 hours of treatment.Results The LVEF and LVEDD of the study group after 24 hours of treatment and 48 hours after treatment were better than those of the control group,the diff erence was statistically signifi cant(P<0.05);the dose and frequency of morphine use in the study group were less than those of the control group,and the diff erence was statistically signifi cant signifi cance(P<0.05).Conclusion Compared with routine treatment,the clinical eff ect of applying dexmedetomidine on the basis of conventional treatment is more signifi cant.It can increase LVEF while reducing LVEDD,reducing the dosage and frequency of morphine use.