类风湿性关节炎患者感染因素及免疫球蛋白表达意义探究

Infection factors and significance of immunoglobulin expression in patients with rheumatoid arthritis

目的探究类风湿性关节炎患者感染的相关因素及免疫球蛋白表达意义。方法选取2018年3月至2019年3月本院收治的类风湿性关节炎合并感染患者40例为观察组,选取同期入院治疗的非感染类风湿性关节炎患者40例为对照组,并随机选取同期80例健康体检人群为健康人群组。比较两组患者的相关临床指标,同时比较类风湿性关节炎患者与健康人群免疫球蛋白水平,探究类风湿性关节炎患者合并感染的相关因素。结果观察组患者血沉、C反应蛋白含量明显高于对照组(P<0.05);类风湿性关节炎患者IgG、IgM、IgA表达量明显高于健康人群(P<0.05);血沉和C反应蛋白水平是类风湿性关节炎合并感染的影响因素,与类风湿性关节炎合并感染相关(P<0.05)。结论血沉和C反应蛋白水平是类风湿性关节炎合并感染的影响因素,与类风湿性关节炎合并感染相关。类风湿性关节炎患者免疫球蛋白水平高,其发病中可能存在自身体液免疫环节。

Objective To explore the infection factors and immunoglobulin expression significance in patients with rheumatoid arthritis.Methods 40 patients with co-infected rheumatoid arthritis admitted to our hospital from March 2018 to March 2019 were selected as the observation group,40 patients with non-infected rheumatoid arthritis admitted to the hospital during the same period were selected as the control group,and 80 healthy people were included in the healthy group during the same period.The relevant clinical indicators of the observation group and the control group,the levels of immunoglobulin in patients with rheumatoid arthritis and healthy people were compared,and the related factors of rheumatoid arthritis patients with infection were explored.Results The levels of erythrocyte sedimentation rate(ESR)and C-reactive protein in the observation group were significantly higher than those in the control group(P<0.05).The levels of IgG,IgM,and IgA expression were significantly higher than those in the healthy population(P<0.05).Erythrocyte sedimentation rate and C-reactive protein levels are the influencing factors of infection associated with rheumatoid arthritis,and are associated with rheumatoid arthritis co-infection(P<0.05).Conclusion Erythrocyte sedimentation rate and C-reactive protein levels are the influencing factors of infection associated with rheumatoid arthritis,and are associated with rheumatoid arthritis coinfection patients with rheumatoid arthritis have high levels of immunoglobulins,and their humoral immune link may exist in the pathogenesis.