α-酮戊二酸的生物学功能及分子机制研究进展

Advances in the Biological Functions and Molecular Mechanisms of Alpha-ketoglutaric Acid

骨骼肌在收缩过程中可以释放多种生物活性代谢中间产物,这些小分子代谢中间产物可以通过自分泌、旁分泌和内分泌等方式调节动物机体活动。α-酮戊二酸(Alpha-Ketoglutaric Acid,AKG)是一种已知的重要生物活性代谢中间产物,在调节肌肉、骨骼发育、干细胞分化和细胞代谢中发挥着重要作用,还可调节机体的免疫和炎症反应。本文综述了AKG的生物学功能及其分子机制方面的研究进展,为进一步拓宽AKG在畜禽生产和人类临床医学中的应用提供依据。

During the process of skeletal muscle contraction,a variety of myometabolites can be released.These small molecules can regulate the activities of animals by means of autocrine,paracrine and endocrine.Alpha-ketoglutaric acid(AKG)is a known important myometabolites,plays an important role in regulating muscle development and bone growth and cell metabolism,as well as strengthening the body's immunity and inducing the renewal and differentiation of stem cells.This article summarizes the research progress in the biological function and molecular mechanism of AKG,and provides a basis for further broadening the application of AKG in livestock and poultry production and human clinical medicine.