3种不同痰诱导液用于AECOPD患者的排痰效果及安全性比较

Study on the efficacy and safety of three different sputum induction fluids in AECOPD patients

目的探讨慢性阻塞性肺疾病急性加重(AECOPD)的患者应用不同痰诱导液的排痰效果及安全性。方法选择AECOPD的患者300例,按入院先后顺序分为3组,使用3种不同的痰诱导液进行痰诱导,A组予0.9%的氯化钠溶液,B组予3%的氯化钠溶液,C组予10%的N-乙酰半胱氨酸雾化液。在痰液诱导过程中均予床边心电监护并隔5 min行床边肺功能检查,记录观察第1秒用力呼气容积(FEV1)、心率(HR)、血氧饱和度(SpO2)、诱导排痰时间及患者的自觉症状。结果在总体诱导排痰成功率方面,B组和C组较A组有显著优势;在诱导排痰时效性方面,5~10 min内C组排痰成功率最高,B组次之,A组最差。在诱导排痰安全性方面,A组与C组的安全性较高,B组最差。结论用10%的N-乙酰半胱氨酸雾化液对AECOPD患者进行痰液诱导是一种既安全又有效的方法。

Objective To investigate the efficacy and safety of sputum induction in patients with AECOPD using three different sputum induction fluids.Methods Three hundreds patients with AECOPD were selected and divided into 3 groups in the order of admission.Three different sputum induction fluids were used,Group A(0.9%sodium chloride solution),Group B(3%chloride Sodium solution),an Group C(10%N-acetylcysteine atomizing solution).During the induction of sputum,bedside ECG monitoring was performed and bedside lung function tests were performed every 5 minutes.FEV〕,HR,SpO2,induction of sputum excretion time,and patient's symptoms were recorded and observed.Results In terms of the overall success rate of induced sputum excretion,Group B and C had significant advantage over Group A.Within 5-10 minutes,the successful rate of sputum excretion was the highest in Group C,followed by Group B,and the worst in Group A.The safeties of Group A and C were higher than Group B.Conclusion Using 10%N-acetylcysteine nebulizing solution to induce sputum in patients with AECOPD is safe and effective.