12例新型冠状病毒肺炎患者临床特征分析

Analysis of clinical characteristics of 12 patients with COVID-19

目的分析新型冠状病毒肺炎(新冠肺炎)的临床和流行病学特征,为疫情防控提供参考。方法收集2020-01-26至2020-04-05成都市中西医结合医院第二临床观察科确诊的12例新冠肺炎患者临床资料,对其基本信息、流行病学史、实验室检查、胸部CT等进行调查研究。结果新冠肺炎患者男性多于女性,男女比为1.4∶1;病例以40岁以上中老年为主,普通型患者多于重型患者,重型与普通型比为1∶5;前期主要为本土病例,2月中旬之后主要为境外输入病例;本土病例中75%有武汉/湖北旅居史或新冠肺炎确诊患者密切接触史,潜伏期最短4天、最长11天;临床症状以发热、咳嗽、恶寒为主,白细胞未见明显升高,超敏-C反应蛋白升高,胸部CT以双肺磨玻璃样改变为主。重型患者白细胞、中性粒细胞、淋巴细胞、中性粒细胞百分比低于普通型患者,淋巴细胞百分比、超敏C-反应蛋白、胸部CT评分高于普通型患者。结论新冠肺炎患者以男性为主,40岁以上为高发人群,发热是其最主要的临床症状,重型患者超敏C反应蛋白明显升高,胸部CT病灶明显。

Objective To analyze the clinical and epidemiological characteristics of corona virus disease-2019(COVID-19),and to provide reference for epidemic prevention and control.Methods From January 26 to April 5,2020,the clinical data of 12 patients with COVID-19 in the Second Clinical Observation Department of Chengdu Integrated TCM&Western Medicine Hospital were collected for their basic information,epidemiological history,laboratory examinations,chest CT and so on.Results There were more males patients than females patients,with a male to female ratio of 1.4∶1.The disease was mainly concentrated on the middle-aged and elderly people older than 40 years old,and the number of common patients was bigger than that of severe patients,with a ratio of 1∶5.In the early stage,the cases were mainly indigenous,while after mid-February,they were mainly imported from foreign countries.75%of the local cases had a history of Wuhan/Hubei travel or close contact with patients with COVID-19,and the shortest incubation period was 4 days and the longest was 11 days.The main clinical symptoms were fever,cough,and cold.There was no significant increase in white blood cells and high sensitivity C-reactive protein.The main changes of chest CT were ground glass in both lungs.Compared with severe patients,the common patients had higher percentages of white blood cells,neutrophils and lymphocytes,while they had lower percentages of lymphocytes and hypersensitive C-reactive protein,and lower chest CT scores.Conclusion COVID-19 is mainly concentrated on males,and people older than 40 years old are at a high risk.Fever is the main clinical symptom.In severe patients,the hypersensitive C-reactive protein significantly increases,and the chest CT lesions are obvious.