摘要
目的:考察氯霉素泼尼松搽剂皮肤用药的安全性。方法:分别对健康家兔进行皮肤急性毒性试验、皮肤刺激性试验,对健康豚鼠进行皮肤过敏性试验。结果:氯霉素泼尼松搽剂对家兔完整皮肤、破损皮肤均无明显急性毒性和局部刺激性,对豚鼠皮肤无过敏反应。结论:氯霉素泼尼松搽剂短期皮肤用药是安全的。
Objective: To investigate the application safety of chloramphenicol prednisone liniment. Methods: Acute skin toxicity and skin irritation were carried out on healthy rabbits, and skin allergic reaction was performed on healthy guinea pigs. Results:Chloramphenicol prednisone liniment had no obvious acute toxicity and local irritation to integral and damaged skin of rabbits,and no allergic reaction to the skin of guinea pigs. Conclusion: Chloramphenicol prednisone liniment is safe for short-term skin application.
作者
陈少秀
杜晓
景海霞
张霞
常明泉
Chen Shaoxiu;Du Xiao;Jing Haixia;Zhang Xia;Chang Mingquan(Shiyan Taihe Hospital,Ailiated Taihe Hospial of Hubei Unirersity of Medicine,Hubei Shiyan 442000,China)
出处
《儿科药学杂志》
CAS
2020年第10期5-7,共3页
Journal of Pediatric Pharmacy
基金
十堰市太和医院院级基金项目,编号2017JJXM056。
关键词
氯霉素泼尼松搽剂
皮肤急性毒性
皮肤刺激性
皮肤过敏试验
chloramphenicol prednisone liniment
acute dermal toxicity
dermal irritation
skin allergic reaction