西咪替丁治疗慢性结肠炎13例

13 cases of cimetidine in the treatment of chronic colitis

目的:分析西咪替丁治疗慢性结肠炎13例的疗效。方法:2017年5月-2018年9月收治慢性结肠炎患者13例,均接受西咪替丁治疗,分析临床效果。结果:治疗总有效率为100%,其中显效10例,有效3例;且均未出现不良反应。所有患者治疗后黏液脓血便、腹痛、腹泻、里急后重及肛门灼热等症状积分均明显低于治疗前,差异有统计学意义(P<0.05)。所有患者治疗后所有患者血清细胞介素-10(IL-10)值与CD4+CD25+调节性T细胞比例明显提高,差异有统计学意义(P<0.05)。所有患者治疗后结肠镜积分与病理积分均明显低于治疗前,差异有统计学意义(P<0.05)。结论:西咪替丁治疗慢性结肠炎,疗效确切,患者临床症状得到明显改善。

Objective:To analyze the therapeutic effect of cimetidine on 13 cases of chronic colitis.Methods:From May 2017 to September 2018,13 patients with chronic colitis were selected and treated with cimetidine,which the clinical effect was analyzed.Results:The total therapeuticeffective rate was 100%,including 10 cases with obvious effect and 3 cases with effective effect.There were no adverse reactions.Aftertreatment,thesymptom scores of mucous pusblood stool,abdominalpain,diarrhea,tenesmus and anal burning were significantly lower than before treatment in all patients,withthe differences were statistically significant(P<0.05).After treatment,the serum IL-10 value and the proportion of CD4+CD25+ regulatory T cells in all patients were significantly increased(P<0.05).Colonoscopy integrals and pathology integrals of all patients were significantly lower after treatment than before treatment,withthe differences were statistically significant(P<0.05).Conclusion:Cimetidine in the treatment of chronic colitis,the curative effect is definite and the clinical symptoms of the patients were significantly improved.