长链非编码RNA调控成骨分化的研究现状及展望

Research progress and prospects of long non⁃coding RNA regulating osteogenic differentiation

颅颌面骨缺损或异常不仅会造成相应功能的障碍,还会影响患者的美观及心理健康。间充质干细胞向成骨细胞谱系分化是骨组织发生与形成的物质基础,也是维持骨稳态的重要因素。成骨分化异常既与多种骨相关疾病有着密切关系,也会对骨组织修复产生消极影响。长链非编码RNA作为近年来新发现的调控因子,在成骨分化过程中发挥着重要的作用。本文拟阐述目前在成骨分化方面起重要调控作用的lncRNA及其机制,并探讨目前研究存在的不足及未来的发展前景。

Defect and abnormity of craniofacial bones not only cause corresponding functional disorders,but also affect the outlooking and mental health of patients. The osteogenic differentiation from mesenchymal stem cells to osteoblast lineage is not only the foundation of osteogenesis,but also one of the key factors maintaining bone homeostasis.Abnormal osteogenic differentiation is strongly relative to many bone diseases and has side effects on bone regeneration. As a newly discovered regulatory factor,long non-coding RNA plays an important role in osteogenic differentiation. This article focused on the long non-coding RNA that played important roles in regulating osteogenic differentiation,discussing the mechanisms,existing problems as well as prospects.