基于SOCS通路探讨糖尿病足溃疡治疗中中药“去腐生新”作用的研究进展

Research progress of traditional Chinese medicine in the treatment of diabetic foot ulcer based on SOCS pathway

糖尿病足溃疡(DFUs)是糖尿病严重的并发症之一,发病率和截肢率高,目前具体发病机制仍未完全明确。相关研究表明,炎症、感染和营养障碍等多种因素共同影响DFUs的转归及预后。抑制相关炎症通路和细胞因子表达,可促使坏死组织脱落促进愈合。此外,细胞因子信号传导抑制因子家族蛋白(SOCS)可通过激活蛋白酪氨酸激酶(JAK)/信号转导和转录活化因子(STAT)信号通路参与细胞因子信号转导,参与DFUs创面炎症反应以及愈合过程。近年来,大量研究发现具有“去腐生新”功效的单味中药及其活性成分、中药复方对DFUs具有很好的疗效,研究中药治疗DFUs的具体机制已成为近些年来研究的热点之一。文章查阅近年文献,就SOCS通路与DFUs的关系及中医药治疗DFUs作用机制进行综述。

Diabetic foot ulcers(DFUs)is one of the serious complications of diabetes mellitus,with high morbidity and amputation rate.At present,the specific pathogenesis is still unclear.Related studies have shown that inflammation,infection and nutritional disorders together affect the prognosis of diabetic foot ulcer,inhibit the expression of related inflammatory pathways and cytokines,and promote the abscission of necrotic tissue to promote healing.In addition,the suppressor of cytokine signaling(SOCS)can participate in cytokine signal transduction,wound inflammation and healing process of DFUs by activating JAK-STAT signal pathway.In recent years,a large number of studies have found that the single drug and its active ingredients with the effect of“removing the decay and generating new”and the Chinese herbal compound have very good curative effect on DFUs.In recent years,the research on the specific mechanism of the treatment of DFUs by Chinese herbal medicine has become one of the hot spots of research.In this paper,the author reviewed the recent literature on the relationship between SOCS pathway and DFUs and the mechanism of traditional Chinese medicine in the treatment of DFUs.