Recent progress in tumor photodynamic immunotherapy

Photodynamic therapy(PDT)is a promising alternative approach for effective cancer treatment,which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species(ROS)in the tumor cells.Intriguingly,PDT-mediated cell death is also associated with anti-tumor immune response.Howeve r,immunosuppre s sion of tumor microe nvironment is able to limit the immune response induced by PDT,it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors.Herein,the recent advances of PDT,immunotherapy,and photodynamic immunotherapy are reviewed.